Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2534677..2535898 Replicon chromosome
Accession NZ_CP050053
Organism Pseudomonas aeruginosa strain LIUYANG-C

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HAP36_RS11915 Protein ID WP_003114949.1
Coordinates 2534677..2535255 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HAP36_RS11920 Protein ID WP_003088112.1
Coordinates 2535344..2535898 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAP36_RS11900 2529954..2531231 + 1278 WP_003102743.1 TolC family protein -
HAP36_RS11905 2531221..2533392 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
HAP36_RS11910 2533382..2534569 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
HAP36_RS11915 2534677..2535255 - 579 WP_003114949.1 HD domain-containing protein Toxin
HAP36_RS11920 2535344..2535898 - 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
HAP36_RS11925 2536056..2538251 - 2196 WP_003114948.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
HAP36_RS11930 2538256..2538717 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
HAP36_RS11935 2539048..2539371 + 324 WP_003102734.1 multidrug efflux SMR transporter -
HAP36_RS11940 2539384..2539782 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
HAP36_RS11945 2539779..2540330 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T152163 WP_003114949.1 NZ_CP050053:c2535255-2534677 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T152163 NZ_CP066016:3452801-3453190 [Acinetobacter baumannii]
TTGCTCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATAAGCTTTATTTTCTTTT
TAAAGCGTCCGCAACTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT152163 WP_003088112.1 NZ_CP050053:c2535898-2535344 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT152163 NZ_CP066016:3452537-3452794 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References