Detailed information of TA system TA152162

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1602236..1603494
• Replicon: chromosome
• Accession: NZ_CP050053
• Organism: Pseudomonas aeruginosa strain LIUYANG-C

Toxin (Protein)

• Gene name: -
• Uniprot ID: Q9I4U4
• Locus tag: HAP36_RS07550
• Protein ID: WP_003112528.1
• Coordinates: 1602739..1603494 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: HAP36_RS07545
• Protein ID: WP_003086329.1
• Coordinates: 1602236..1602604 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAP36_RS07525	1598399..1598674	+	276	WP_010793902.1	zinc ribbon domain-containing protein	-
HAP36_RS07530	1598677..1599153	-	477	WP_003112531.1	hypothetical protein	-
HAP36_RS07535	1599232..1600821	+	1590	WP_010895535.1	aldehyde dehydrogenase family protein	-
HAP36_RS07540	1600877..1602163	+	1287	WP_003112529.1	FAD-binding oxidoreductase	-
HAP36_RS07545	1602236..1602604	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
HAP36_RS07550	1602739..1603494	+	756	WP_003112528.1	RES family NAD+ phosphorylase	Toxin
HAP36_RS07555	1604262..1605623	+	1362	WP_010895536.1	DNA recombination protein RmuC	-
HAP36_RS07560	1605778..1608321	-	2544	WP_003112526.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28278.42 Da
• Isoelectric Point: 7.7294

>T152162 WP_003112528.1 NZ_CP050053:1602739-1603494 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T152162 NZ_CP066015:2606289-2606681 [Kytococcus sedentarius]
GTGATCGTCGACTCCTCGGCCCTCGTGGCCATCCTGTTGGCAGAGCCGGAGCGCCAGGCCCTCCTCGAGGCCATCCAGCA
GGCCCCGGAGGCCGCGATGACCGCGGCCTCCTACCTCGAGGTGGGCATGGTGGTGGACGGGCGGGGAAACCCGGTCCTCT
CTCGCCAGTACGACGCCCTGTTGGAGGCCCTCGGTATCGAGGTGGTGGACACCACGGCCGAGCAGGCCCGTGTCGCCCGG
GCGGCGCACCGGGACTTCGGCCGGGGGAGTGGGCACCCGGCGCGCCTGAACTTCGGGGACTGCCTCAGCTACGCCGCCGC
CGTCCAGGATGGGGTCCCCTTGTTGTTCACGGGTGACGACTTCATCCACACGGACGTCACGCCTGCCCGCTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT152162 WP_003086329.1 NZ_CP050053:1602236-1602604 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT152162 NZ_CP066015:2606044-2606292 [Kytococcus sedentarius]
ATGGCACTCACGATCAAGAACGACAGGGTGTGCGACCTGGCCCGCGAGGCGGCGCAGCGCTCGGGACAGTCCCAGGTGTC
CGTCATCGAGCAGGCGTTGGAGCGATACCTGGCCGACCATGCCGAGCCCGTGGGGCGGCGCGTGGACGAGGTGCTCGCCC
GCATCGACGCCAGCCTTGCCCCGGGGGATGCTGCCGCGATGCGCGTCGAGCTCGATCGCCTCTACGACGAACGGGGGCTC
CCCGCGTGA

Structures

Toxin

• AlphaFold DB: Q9I4U4

Antitoxin

• AlphaFold DB: V6AJU7