Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 706233..706926 Replicon chromosome
Accession NZ_CP050040
Organism Escherichia coli strain 63-2

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag G9P50_RS03360 Protein ID WP_000415584.1
Coordinates 706233..706529 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag G9P50_RS03365 Protein ID WP_000650107.1
Coordinates 706531..706926 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9P50_RS03325 701321..701635 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
G9P50_RS03330 701666..702247 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
G9P50_RS03335 702566..702898 + 333 WP_000917684.1 DUF2645 family protein -
G9P50_RS03340 702944..704293 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
G9P50_RS03345 704290..704949 - 660 WP_001221493.1 two-component system response regulator QseB -
G9P50_RS03350 705101..705493 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
G9P50_RS03355 705546..706028 + 483 WP_000183505.1 transcriptional regulator -
G9P50_RS03360 706233..706529 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
G9P50_RS03365 706531..706926 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
G9P50_RS03370 707059..708666 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
G9P50_RS03375 708804..711062 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T152075 WP_000415584.1 NZ_CP050040:706233-706529 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T152075 NZ_CP065949:329319-329687 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT152075 WP_000650107.1 NZ_CP050040:706531-706926 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT152075 NZ_CP065949:329101-329322 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References