Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4150403..4151022 Replicon chromosome
Accession NZ_CP049950
Organism Klebsiella pneumoniae strain 19KM1053

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag G9174_RS20600 Protein ID WP_002892050.1
Coordinates 4150804..4151022 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag G9174_RS20595 Protein ID WP_002892066.1
Coordinates 4150403..4150777 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9174_RS20585 4145555..4146748 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G9174_RS20590 4146771..4149917 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
G9174_RS20595 4150403..4150777 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
G9174_RS20600 4150804..4151022 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
G9174_RS20605 4151181..4151747 + 567 WP_002892030.1 maltose O-acetyltransferase -
G9174_RS20610 4151719..4151859 - 141 WP_004147370.1 hypothetical protein -
G9174_RS20615 4151880..4152350 + 471 WP_002892026.1 YlaC family protein -
G9174_RS20620 4152325..4153776 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
G9174_RS20625 4153877..4154575 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
G9174_RS20630 4154572..4154712 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
G9174_RS20635 4154712..4154975 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T151851 WP_002892050.1 NZ_CP049950:4150804-4151022 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T151851 NZ_CP065789:518539-518889 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT151851 WP_002892066.1 NZ_CP049950:4150403-4150777 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT151851 NZ_CP065789:518253-518534 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References