Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4015584..4016277 Replicon chromosome
Accession NZ_CP049852
Organism Escherichia coli strain UPEC-774U/190308

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag G9W34_RS19480 Protein ID WP_000415584.1
Coordinates 4015981..4016277 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag G9W34_RS19475 Protein ID WP_000650107.1
Coordinates 4015584..4015979 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W34_RS19465 (4011448) 4011448..4013706 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
G9W34_RS19470 (4013844) 4013844..4015451 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
G9W34_RS19475 (4015584) 4015584..4015979 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
G9W34_RS19480 (4015981) 4015981..4016277 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
G9W34_RS19485 (4016482) 4016482..4016964 - 483 WP_000183505.1 GyrI-like domain-containing protein -
G9W34_RS19490 (4017017) 4017017..4017409 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
G9W34_RS19495 (4017561) 4017561..4018220 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
G9W34_RS19500 (4018217) 4018217..4019566 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
G9W34_RS19505 (4019612) 4019612..4019944 - 333 WP_000917685.1 DUF2645 family protein -
G9W34_RS19510 (4020263) 4020263..4020844 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
G9W34_RS19515 (4020875) 4020875..4021189 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4007121..4016277 9156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T151731 WP_000415584.1 NZ_CP049852:c4016277-4015981 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T151731 NZ_CP065688:c3888591-3888409 [Serratia plymuthica]
GTGAAAAGTTCAGAACTGATCAGGCTGTTAGAACGAGAAGGTTGGGTTTTAGAGCGGATAAAGGGAAGCCACCATCAGTT
TAAACACCCGGGATCTCGTTTGGTGATCACCGTTCCACACCCGCGTAAAGATCTGAAGCCGGGAACGCTGCGCCAGATCA
TGAAAGATGCCGGGCTGTGCTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT151731 WP_000650107.1 NZ_CP049852:c4015979-4015584 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT151731 NZ_CP065688:c3888379-3887966 [Serratia plymuthica]
ATGTTCTACCCTGCTTATGTACATTCAGACCTCGACGGCAGCGCCAGCGGTTTCTTCCCCGATGTGCCGGGCTGTTATTT
TGCCGGCGATACCCTCGATAAAGCCTTTGAAGATGCCAAAGGCGCGCTGGATGCGCATTTCGAACTTCTGAGCGAAGACA
ACCAGGCCATTCCGCGCCCACAGGCCGTTTCCTTCCATCTGGCACAGGAAAACGACACCCTGAACGGCGGGCAGTGGCTG
CTGGTCGATATCAATATGGATAAGTTCGATGGGCGGGCGGAACGTATCAATATCACTCTGCCGCACCGCTTGCTGAACCG
CATCGATTCACTGGTGCAGCAGCATCCTGGCTATGGGAGCCGCAGCGCCTTTTTGGCCGCCGCCGCCCGTAATGAATTAT
TGAAAGTCGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References