Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3396545..3397073 Replicon chromosome
Accession NZ_CP049845
Organism Escherichia coli strain UPEC-245U/190328

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag G9W35_RS16435 Protein ID WP_233010624.1
Coordinates 3396843..3397073 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag G9W35_RS16430 Protein ID WP_000147082.1
Coordinates 3396545..3396853 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G9W35_RS16385 (3391578) 3391578..3391778 + 201 WP_000437871.1 Cro/CI family transcriptional regulator -
G9W35_RS16390 (3391917) 3391917..3392213 + 297 WP_000438525.1 CII family transcriptional regulator -
G9W35_RS16395 (3392228) 3392228..3392446 + 219 WP_000438870.1 hypothetical protein -
G9W35_RS16400 (3392467) 3392467..3393549 + 1083 WP_238020763.1 DNA-binding protein -
G9W35_RS16405 (3393556) 3393556..3394296 + 741 WP_021565210.1 ATP-binding protein -
G9W35_RS16410 (3394322) 3394322..3395092 + 771 WP_181047569.1 DUF1627 domain-containing protein -
G9W35_RS16415 (3395108) 3395108..3395539 + 432 WP_000196185.1 DUF977 family protein -
G9W35_RS16420 (3395572) 3395572..3396246 - 675 WP_032144013.1 DUF4145 domain-containing protein -
G9W35_RS16425 (3396245) 3396245..3396490 + 246 WP_000354247.1 hypothetical protein -
G9W35_RS16430 (3396545) 3396545..3396853 - 309 WP_000147082.1 helix-turn-helix transcriptional regulator Antitoxin
G9W35_RS16435 (3396843) 3396843..3397073 - 231 WP_233010624.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G9W35_RS16440 (3397490) 3397490..3398182 + 693 WP_115726473.1 ORF6N domain-containing protein -
G9W35_RS16445 (3398237) 3398237..3398647 + 411 WP_042014379.1 recombination protein NinB -
G9W35_RS16450 (3398644) 3398644..3398835 + 192 WP_001254269.1 NinE family protein -
G9W35_RS16455 (3398859) 3398859..3399149 + 291 WP_024194163.1 DUF1364 domain-containing protein -
G9W35_RS16460 (3399146) 3399146..3399508 + 363 WP_181047570.1 RusA family crossover junction endodeoxyribonuclease -
G9W35_RS16465 (3399505) 3399505..3399705 + 201 WP_000994506.1 protein ninH -
G9W35_RS16470 (3399698) 3399698..3400078 + 381 WP_032218107.1 antiterminator Q family protein -
G9W35_RS16475 (3400213) 3400213..3400806 + 594 WP_033808210.1 hypothetical protein -
G9W35_RS16480 (3401776) 3401776..3401848 - 73 Protein_3216 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3373856..3509366 135510


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(5-70)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-97)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8706.22 Da        Isoelectric Point: 10.5886

>T151693 WP_233010624.1 NZ_CP049845:c3397073-3396843 [Escherichia coli]
MRIYGANLGSPHTEAFGDGLFEIRLKGSEGIGRVFYCTLKGKRIIMLHSFVKKTQKTPPAELRKAETRMKEVKHDW

Download         Length: 231 bp

>T151693 NZ_CP065668:c5169161-5168670 [Delftia acidovorans]
ATGAGCGCCGTACCGCCCGCCCCCTTGCGCATCCACGGCTGGACGGTATTCATGCACCCGCTTTTCCTTGCCCAGCTGCA
GGCGTTGAGCCAGGAAGTGGAGGGTCTGAAAACGAAGGACCCTGGCGGGTACACACGCAAGAACGCGACCAAGCGATTGG
CGGCGATCCGCAAGCTGGCATTCGATGTCATCCCGCAGGATCCCACGCGGCCAGACTACCGCCAGGGCCATACCCTGGGC
GAGGAGCACAAGCACTGGTTTCGGGCCAGGTTCTTCCAGCAGTACCGCCTGTTCTTCCGCTTTCACGTCCCCAGCAAAAT
CATCGTGTTCGCCTGGGTCAACGATGAGGACACCAAGCAAGCCTATGAGGGCAGCGACGATGCCTACAGGGTGTTCCGAA
AAATGCTCGCCAACGGGCACCCTCCTGGCGATTGGGACAGTTTGCTGGCACAGGCGAAGTCCCCGCCATCCCGCTCACCG
CCGCACGCCTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11079.81 Da        Isoelectric Point: 9.7256

>AT151693 WP_000147082.1 NZ_CP049845:c3396853-3396545 [Escherichia coli]
MTGKRTPPTMTHDEMVEKMLSNPAVKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGTSG
PSFATLKKFARATGKKLQIRFV

Download         Length: 309 bp

>AT151693 NZ_CP065668:c5169487-5169158 [Delftia acidovorans]
ATGTTTTCGACACTTGAAGCCGAATCCACGCTCACTGACCGCTACCAGACCACCATTCCCGAAGCCGTTCGCCGCGCATT
GCACCTGAGCAAGCGCGACAGGATCCACTACACCATCCTGCCCGGCGGTGAGGTCGTGCTCAGTCGCGCCGACTCCGCCG
AGGATGCCGATCCCGTGCTGGGCCAGTTTCTCGGCTTTCTGGCCCAGGACATGGCAGCCCACCCCGAGCGCCTGCAGACC
ATGGATGCCCGTCTGGCGCAGCAGATCCAGGCGCTGACCGAAGGCATCGAGGTCGATCTGGATGCACCGCTTCTGGCAGA
CGACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References