Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 2959946..2960448 | Replicon | chromosome |
| Accession | NZ_CP049845 | ||
| Organism | Escherichia coli strain UPEC-245U/190328 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | G9W35_RS14165 | Protein ID | WP_000767829.1 |
| Coordinates | 2960194..2960448 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | G9W35_RS14160 | Protein ID | WP_001259255.1 |
| Coordinates | 2959946..2960197 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G9W35_RS14135 (2955124) | 2955124..2956191 | - | 1068 | WP_016232166.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| G9W35_RS14140 (2956191) | 2956191..2957261 | - | 1071 | WP_000108986.1 | histidinol-phosphate transaminase | - |
| G9W35_RS14145 (2957258) | 2957258..2958562 | - | 1305 | WP_074499979.1 | histidinol dehydrogenase | - |
| G9W35_RS14150 (2958568) | 2958568..2959467 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| G9W35_RS14155 (2959613) | 2959613..2959663 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| G9W35_RS14160 (2959946) | 2959946..2960197 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| G9W35_RS14165 (2960194) | 2960194..2960448 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| G9W35_RS14170 (2960531) | 2960531..2961355 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| G9W35_RS14175 (2961401) | 2961401..2962330 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| G9W35_RS14180 (2962545) | 2962545..2962607 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| G9W35_RS14185 (2962597) | 2962597..2963955 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| G9W35_RS14190 (2964134) | 2964134..2965192 | + | 1059 | WP_074499977.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| G9W35_RS14195 (2965206) | 2965206..2965433 | + | 228 | WP_074499976.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T151684 WP_000767829.1 NZ_CP049845:2960194-2960448 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T151684 NZ_CP065666:348040-348426 [Acinetobacter johnsonii]
ATGGAACATCGTCATTTTCAACTTAAACCCAGCCGTTTGGCTTATGTGTTTCAGTTGTCGATTTATGCCGTTCTGATGCT
GGTCCTGTATCAGCTACTTCCTTTTGGACTGTGGCTGATCGCTTTGGTTGCTGGCTTTGTGCTGTATTTGTTTTTTCTAC
GTGGGCCGCAACATTTTCAGCTTCAGCATTTAGATGGCCGTGATTGGTCTTTGTCACTTCAGAAACAAACCAATGCGCAA
CGCGTTCAAATCAGCCATATTGTGGATCATCGTGCTTATATTGTGATTTATTTTCAACATTTTAGAGCAAAACCGATGTT
GGTTTGGTGTGATCAGTTACCCATCACGCAATGGAAAGCCCTGAAAATACTTACTAAAATGCAATAA
ATGGAACATCGTCATTTTCAACTTAAACCCAGCCGTTTGGCTTATGTGTTTCAGTTGTCGATTTATGCCGTTCTGATGCT
GGTCCTGTATCAGCTACTTCCTTTTGGACTGTGGCTGATCGCTTTGGTTGCTGGCTTTGTGCTGTATTTGTTTTTTCTAC
GTGGGCCGCAACATTTTCAGCTTCAGCATTTAGATGGCCGTGATTGGTCTTTGTCACTTCAGAAACAAACCAATGCGCAA
CGCGTTCAAATCAGCCATATTGTGGATCATCGTGCTTATATTGTGATTTATTTTCAACATTTTAGAGCAAAACCGATGTT
GGTTTGGTGTGATCAGTTACCCATCACGCAATGGAAAGCCCTGAAAATACTTACTAAAATGCAATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT151684 WP_001259255.1 NZ_CP049845:2959946-2960197 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT151684 NZ_CP065666:347777-348034 [Acinetobacter johnsonii]
ATGACTGAAGAAATGAGCCTAGAAGAACGTAAAGTAATCTACCGTGCACGTCGTGGTTTAAAAGAAATTGATGTGTACTT
TGACCCTTATGTGAAAAATTATTATCTTCAGGCGGATTCTGCAGAAAAGGCCATGTTTGCGGCCTTGGTTGAACAAGAAG
ATCCTGATTTGCTGGATTGGTTTATGGAAGTCTCTGAGCCGCCGCACCCTGAAATGAAAACATTGATTCAAAAATTAAAG
CATTATGTACACGGATAA
ATGACTGAAGAAATGAGCCTAGAAGAACGTAAAGTAATCTACCGTGCACGTCGTGGTTTAAAAGAAATTGATGTGTACTT
TGACCCTTATGTGAAAAATTATTATCTTCAGGCGGATTCTGCAGAAAAGGCCATGTTTGCGGCCTTGGTTGAACAAGAAG
ATCCTGATTTGCTGGATTGGTTTATGGAAGTCTCTGAGCCGCCGCACCCTGAAATGAAAACATTGATTCAAAAATTAAAG
CATTATGTACACGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|