Detailed information of TA system TA151642

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-agrB/SymE(toxin)
• Location: 612058..612470
• Replicon: chromosome
• Accession: NZ_CP049839
• Organism: Escherichia coli strain UPEC-455U/190220

Toxin (Protein)

• Gene name: symE
• Uniprot ID: S1NWQ7
• Locus tag: G9W36_RS02940
• Protein ID: WP_000132614.1
• Coordinates: 612058..612399 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	agrB
Locus tag	-
Coordinates	612394..612470 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9W36_RS02920 (607127)	607127..608407	-	1281	WP_001338077.1	DUF445 domain-containing protein	-
G9W36_RS02925 (608592)	608592..609512	+	921	WP_001513532.1	Rpn family recombination-promoting nuclease/putative transposase	-
G9W36_RS02930 (609740)	609740..609820	+	81	WP_020233658.1	hypothetical protein	-
G9W36_RS25345 (609918)	609918..610794	+	877	Protein_572	DUF262 domain-containing protein	-
G9W36_RS25350 (610848)	610848..612011	+	1164	WP_224153787.1	DUF1524 domain-containing protein	-
G9W36_RS02940 (612058)	612058..612399	-	342	WP_000132614.1	endoribonuclease SymE	Toxin
- (612394)	612394..612470	+	77	NuclAT_8	-	Antitoxin
- (612394)	612394..612470	+	77	NuclAT_8	-	Antitoxin
- (612394)	612394..612470	+	77	NuclAT_8	-	Antitoxin
- (612394)	612394..612470	+	77	NuclAT_8	-	Antitoxin
- (612394)	612394..612470	+	77	NuclAT_9	-	Antitoxin
- (612394)	612394..612470	+	77	NuclAT_9	-	Antitoxin
- (612394)	612394..612470	+	77	NuclAT_9	-	Antitoxin
- (612394)	612394..612470	+	77	NuclAT_9	-	Antitoxin
G9W36_RS02945 (612620)	612620..614389	-	1770	WP_001513535.1	restriction endonuclease subunit S	-
G9W36_RS02950 (614389)	614389..615858	-	1470	WP_001387312.1	type I restriction-modification system subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12266.07 Da
• Isoelectric Point: 8.4982

>T151642 WP_000132614.1 NZ_CP049839:c612399-612058 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T151642 NZ_CP065626:c1770920-1770717 [Edwardsiella hoshinae]
ATGACCAAAATCGACTATCTGATGAAGTTGCGTAAGTGCACGTCGCTGGAGACGCTGGAACGCGTGATCGAAAAGAATAA
ATATGAGCTTTCCAATGATGAGCTAGAAATTTTTTATTCCGCTGCCGATCATCGCTTAGCCGAATTAACTATGAATAAGC
TATACGATAAAATTCCGGCCGAAGTCTGGCAATATGTACGCTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT151642 NZ_CP049839:612394-612470 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: S1NWQ7

Antitoxin