Detailed information of TA system TA151631

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 233..804
• Replicon: plasmid pA
• Accession: NZ_CP049831
• Organism: Aeromonas salmonicida subsp. masoucida strain RZ6S-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: G9H43_RS22645
• Protein ID: WP_219934990.1
• Coordinates: 493..804 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q07XG1
• Locus tag: G9H43_RS22640
• Protein ID: WP_011638898.1
• Coordinates: 233..493 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9H43_RS22640 (G9H43_22720)	233..493	+	261	WP_011638898.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
G9H43_RS22645 (G9H43_22725)	493..804	+	312	WP_219934990.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G9H43_RS22650 (G9H43_22730)	828..3914	+	3087	WP_219934991.1	Tn3 family transposase	-
G9H43_RS22655 (G9H43_22735)	3944..4819	+	876	WP_181317832.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	tet(A) / aac(6')-Ib-cr / blaOXA-1 / catB3 / catA2 / ARR-3 / qacE / sul1 / floR / formA	-	1..286000	286000

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-62)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11794.62 Da
• Isoelectric Point: 8.5197

>T151631 WP_219934990.1 NZ_CP049831:493-804 [Aeromonas salmonicida subsp. masoucida]
MPVTYHLTPDAQSDLIGINRFTLAQWGTTQSKTYLSGLRQTIPLLAETPSLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Nucleotide

• Length: 312 bp

>T151631 NZ_CP065624:c1931506-1931231 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9330.74 Da
• Isoelectric Point: 6.4546

>AT151631 WP_011638898.1 NZ_CP049831:233-493 [Aeromonas salmonicida subsp. masoucida]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAMTDIKMGNLVDGNTFFDEL
AAGQYD

Nucleotide

• Length: 261 bp

>AT151631 NZ_CP065624:c1931234-1930875 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A2K8ZVH1