Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 573429..573970 Replicon chromosome
Accession NZ_CP049773
Organism Mesoflavibacter sp. HG96

Toxin (Protein)


Gene name parE Uniprot ID A0A137REF7
Locus tag C7H62_RS02720 Protein ID WP_062623211.1
Coordinates 573668..573970 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A5M7B575
Locus tag C7H62_RS02715 Protein ID WP_028284019.1
Coordinates 573429..573671 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C7H62_RS02680 568476..569033 + 558 WP_106687026.1 hypothetical protein -
C7H62_RS02685 569298..570011 + 714 WP_191073026.1 hypothetical protein -
C7H62_RS02690 570225..570515 + 291 WP_106687046.1 hypothetical protein -
C7H62_RS02695 570525..570740 + 216 WP_106687025.1 hypothetical protein -
C7H62_RS02700 570893..571762 + 870 WP_106687024.1 hypothetical protein -
C7H62_RS02705 571913..572449 + 537 WP_106687023.1 YcxB family protein -
C7H62_RS02710 572605..573240 + 636 WP_106687022.1 hypothetical protein -
C7H62_RS02715 573429..573671 + 243 WP_028284019.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
C7H62_RS02720 573668..573970 + 303 WP_062623211.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C7H62_RS02725 574135..574635 + 501 WP_106687020.1 hypothetical protein -
C7H62_RS02730 574793..575440 + 648 WP_106687019.1 hypothetical protein -
C7H62_RS02735 576038..576817 - 780 WP_106687018.1 patatin-like phospholipase family protein -
C7H62_RS02740 576884..577372 - 489 WP_106687017.1 hypothetical protein -
C7H62_RS02745 577563..577997 - 435 WP_106687016.1 Hsp20/alpha crystallin family protein -
C7H62_RS02750 578088..578564 - 477 WP_106687015.1 Hsp20/alpha crystallin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 523059..583336 60277


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-94)

Antitoxin

Antitoxin ParD

(1-77)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 12257.25 Da        Isoelectric Point: 10.2010

>T151541 WP_062623211.1 NZ_CP049773:573668-573970 [Mesoflavibacter sp. HG96]
MSKNKYRISQQAIEDLDKIWIYTLNKWSKEQADRYYDLIITEIEFIADNFMTGKSAEQTRKNYRVTKIKSHLIFYRKVEN
DIVEIVRILHQRMDIKKRLK

Download         Length: 303 bp

>T151541 NZ_CP065607:c3342615-3342337 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9306.49 Da        Isoelectric Point: 6.8826

>AT151541 WP_028284019.1 NZ_CP049773:573429-573671 [Mesoflavibacter sp. HG96]
MGKNTSISLGNHFEDFIREEVNSGRYGSVSEVIRSALRLLEREEKKERELIKALEVGENSGFVENFDPKQHLKELHRKHL

Download         Length: 243 bp

>AT151541 NZ_CP065607:c3342878-3342618 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A137REF7

Antitoxin

Source ID Structure
AlphaFold DB A0A5M7B575

References