Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1785990..1786606 Replicon chromosome
Accession NZ_CP049737
Organism Pseudomonas sp. AN-B15

Toxin (Protein)


Gene name hicA Uniprot ID A0A0C2MUQ5
Locus tag GTQ41_RS08245 Protein ID WP_041072921.1
Coordinates 1785990..1786202 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID W6W5D4
Locus tag GTQ41_RS08250 Protein ID WP_007961664.1
Coordinates 1786202..1786606 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GTQ41_RS08215 (GTQ41_08225) 1781513..1781983 + 471 WP_041072928.1 cytochrome c-type biogenesis protein CcmH -
GTQ41_RS08220 (GTQ41_08230) 1781980..1783182 + 1203 WP_047292588.1 c-type cytochrome biogenesis protein CcmI -
GTQ41_RS08225 (GTQ41_08235) 1783210..1783614 + 405 WP_047292591.1 hypothetical protein -
GTQ41_RS08230 (GTQ41_08240) 1783673..1784248 - 576 WP_047292593.1 PIN domain-containing protein -
GTQ41_RS08235 (GTQ41_08245) 1784245..1784712 - 468 WP_047292596.1 helix-turn-helix domain-containing protein -
GTQ41_RS08240 (GTQ41_08250) 1784795..1785682 - 888 WP_047292597.1 LysR family transcriptional regulator -
GTQ41_RS08245 (GTQ41_08255) 1785990..1786202 + 213 WP_041072921.1 type II toxin-antitoxin system HicA family toxin Toxin
GTQ41_RS08250 (GTQ41_08260) 1786202..1786606 + 405 WP_007961664.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GTQ41_RS08255 (GTQ41_08265) 1786676..1787863 - 1188 WP_047292599.1 MFS transporter -
GTQ41_RS08260 (GTQ41_08270) 1788107..1788727 + 621 WP_047292601.1 DUF5666 domain-containing protein -
GTQ41_RS08265 (GTQ41_08275) 1788871..1789869 - 999 WP_047292603.1 sulfate ABC transporter substrate-binding protein -
GTQ41_RS08270 (GTQ41_08280) 1790054..1790878 - 825 WP_047292605.1 ion transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8008.25 Da        Isoelectric Point: 10.5305

>T151477 WP_041072921.1 NZ_CP049737:1785990-1786202 [Pseudomonas sp. AN-B15]
VQSRLLIKELEEAGWTLDRVTGSHHIFRHRYNPYTIPVPHPKKDLPLGTVKSIRRRAGLYHPPASCKGDP

Download         Length: 213 bp

>T151477 NZ_CP065534:c2839053-2838721 [Lonsdalea populi]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTTGATTCCACTGCCGGGCATGAGCAAAGCGGAAAACGCCCGGTGCTTAT
CGTTTCACCGGCGCCGTTTAACAAAATCACCCGGTTGCCTGTGGTTGTTCCTGTCACCAGCGGTGGAAACTTTGCCCGAA
CGGCTGGTTTTGCCGTTTCATTGGATGGCACGGGAACGAAAACAACGGGTGTTGTTCGCTGCGACCAGCCCAGAACTATT
GATATGGCGGCCAGAAACGGCAGAAGGCTGGAGCGTATCCCTGACAGTATCGTAAACGAGGTACTGGCCCGACTGGGAAC
AATCCTTACCTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14836.80 Da        Isoelectric Point: 4.2870

>AT151477 WP_007961664.1 NZ_CP049737:1786202-1786606 [Pseudomonas sp. AN-B15]
MQYPICIEWGDDNTAIGIQIPDIPGAVTAGDTFEDAYNAAVEVAHLMLQEMAADGESIPMPTSAAAHRNNPEFADMGWGM
LELDISPYMGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Download         Length: 405 bp

>AT151477 NZ_CP065534:c2839311-2839054 [Lonsdalea populi]
ATGTATACCACTCGTCTGAAAAAAGTCGGAGGATCTGTCATGTTGGCAGTGCCTCCCGCCGTGCTGAAAACGCTGGATTT
GTCGCCGGATAGCGAGGTCGGCGTGACCGTTGATAATGGCTGCCTCATCATTGAACCTCAAAAACGGCCTCACTATTCGC
TTGCCGAACTATTGGCGCAATGCGATCCACATGCCCAAGTAAGTGATGAAGATCGGGAATGGATTGACGCGCCTGCCACA
GGGAAGGAGATCTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C2MUQ5

Antitoxin

Source ID Structure
AlphaFold DB W6W5D4

References