Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 709090..709783 Replicon chromosome
Accession NZ_CP049353
Organism Escherichia coli strain T28R

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag G7B60_RS03370 Protein ID WP_000415584.1
Coordinates 709090..709386 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag G7B60_RS03375 Protein ID WP_000650107.1
Coordinates 709388..709783 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G7B60_RS03335 704178..704492 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
G7B60_RS03340 704523..705104 - 582 WP_000072420.1 NADPH:quinone oxidoreductase MdaB -
G7B60_RS03345 705423..705755 + 333 WP_000917684.1 DUF2645 family protein -
G7B60_RS03350 705801..707150 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
G7B60_RS03355 707147..707806 - 660 WP_001221493.1 two-component system response regulator QseB -
G7B60_RS03360 707958..708350 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
G7B60_RS03365 708403..708885 + 483 WP_000183505.1 transcriptional regulator -
G7B60_RS03370 709090..709386 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
G7B60_RS03375 709388..709783 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
G7B60_RS03380 709916..711523 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
G7B60_RS03385 711661..713919 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T151284 WP_000415584.1 NZ_CP049353:709090-709386 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T151284 NZ_CP065424:c4824395-4824045 [Heyndrickxia oleronia]
TTGATTGTTAAGCGTGGTGACGTGTATTTTGCTGACCTTTCCCCAGTTGTCGGATCTGAACAAGGTGGAGTCCGCCCTGT
TTTGGTCATTCAAAACGACATTGGGAATCGGTTTAGTCCCACTGTAATTGTTGCTGCTATTACAGCGCAAATCCAAAAAG
CAAAACTTCCTACACATGTTGAAATTGATGCAAAGCGTTATGGCTTTGAACGCGATTCTGTTATTTTGCTTGAACAAATT
CGCACCATTGATAAACAACGCTTAACAGACAAAATCACACATTTAGACGAAGAAATGATGGAAAAAGTGGACGATGCACT
GCAAATTAGTTTAGGACTTATTGAATTTTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT151284 WP_000650107.1 NZ_CP049353:709388-709783 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT151284 NZ_CP065424:c4824681-4824400 [Heyndrickxia oleronia]
GTGTCTGAATCCAGCGCAACAACAGAAATATTAATTCGGTTACCAGTACATTTATTATCAGAACTTGATGGATTTGCTGA
GCAAGAAAATGTGAATCGAAATGAATTTATTTATCGAGCTACAAAGATGTATCTTCGTGAGCGTAAAAAAAGACAGATTC
GCGAATCTATGAGACGCGGCTACATGGAAATGGCTAAAATTAATTTAGCAATAGCATCTGAGGCGATTCAAGCAGAGTAC
GAAGCAGAACATACAGTAGAACGCTTAGTAAGCGGGGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References