Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4006256..4006916 Replicon chromosome
Accession NZ_CP049278
Organism Shigella boydii strain 600690

Toxin (Protein)


Gene name cptA Uniprot ID A0A398Q8H4
Locus tag G5S56_RS19665 Protein ID WP_000244782.1
Coordinates 4006256..4006669 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag G5S56_RS19670 Protein ID WP_000354046.1
Coordinates 4006650..4006916 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5S56_RS19645 (4002219) 4002219..4003952 - 1734 WP_000813168.1 single-stranded-DNA-specific exonuclease RecJ -
G5S56_RS19650 (4003958) 4003958..4004668 - 711 WP_078166241.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G5S56_RS19655 (4004693) 4004693..4005589 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
G5S56_RS19660 (4005701) 4005701..4006222 + 522 WP_001055874.1 flavodoxin FldB -
G5S56_RS19665 (4006256) 4006256..4006669 - 414 WP_000244782.1 protein YgfX Toxin
G5S56_RS19670 (4006650) 4006650..4006916 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
G5S56_RS19675 (4007159) 4007159..4008139 + 981 WP_000886099.1 tRNA-modifying protein YgfZ -
G5S56_RS19680 (4008335) 4008335..4008994 - 660 WP_000250274.1 hemolysin III family protein -
G5S56_RS19685 (4009158) 4009158..4009469 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
G5S56_RS19690 (4009514) 4009514..4010947 + 1434 WP_004993952.1 6-phospho-beta-glucosidase BglA -
G5S56_RS19695 (4011004) 4011004..4011748 - 745 Protein_3872 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16305.25 Da        Isoelectric Point: 11.7064

>T151125 WP_000244782.1 NZ_CP049278:c4006669-4006256 [Shigella boydii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQRSR

Download         Length: 414 bp

>T151125 NZ_CP065341:c4681507-4680974 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT151125 WP_000354046.1 NZ_CP049278:c4006916-4006650 [Shigella boydii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT151125 NZ_CP065341:c4681784-4681518 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A398Q8H4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References