Detailed information of TA system TA151004

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4277618..4278030
• Replicon: chromosome
• Accession: NZ_CP049201
• Organism: Escherichia coli strain PapRG-04-4

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: G6Z99_RS20645
• Protein ID: WP_044867306.1
• Coordinates: 4277618..4277959 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4277954..4278030 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6Z99_RS20630	4273627..4275039	-	1413	WP_062892910.1	PLP-dependent aminotransferase family protein	-
G6Z99_RS20635	4275216..4275380	+	165	WP_000397910.1	DUF1127 domain-containing protein	-
G6Z99_RS20640	4275478..4277571	+	2094	WP_164476026.1	DUF262 domain-containing protein	-
G6Z99_RS20645	4277618..4277959	-	342	WP_044867306.1	endoribonuclease SymE	Toxin
-	4277954..4278030	+	77	NuclAT_27	-	Antitoxin
-	4277954..4278030	+	77	NuclAT_27	-	Antitoxin
-	4277954..4278030	+	77	NuclAT_27	-	Antitoxin
-	4277954..4278030	+	77	NuclAT_27	-	Antitoxin
-	4277954..4278030	+	77	NuclAT_28	-	Antitoxin
-	4277954..4278030	+	77	NuclAT_28	-	Antitoxin
-	4277954..4278030	+	77	NuclAT_28	-	Antitoxin
-	4277954..4278030	+	77	NuclAT_28	-	Antitoxin
G6Z99_RS20650	4278187..4279563	-	1377	WP_097315459.1	restriction endonuclease subunit S	-
G6Z99_RS20655	4279560..4281149	-	1590	WP_164476027.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	espX6	4264596..4279563	14967

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12326.12 Da
• Isoelectric Point: 7.8219

>T151004 WP_044867306.1 NZ_CP049201:c4277959-4277618 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPTAEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T151004 NZ_CP065172:c4616744-4616211 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCAGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT151004 NZ_CP049201:4277954-4278030 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin