Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3607506..3608163 Replicon chromosome
Accession NZ_CP049188
Organism Enterobacter hormaechei strain Y323

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag G5C52_RS17095 Protein ID WP_022649305.1
Coordinates 3607753..3608163 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag G5C52_RS17090 Protein ID WP_003863437.1
Coordinates 3607506..3607772 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5C52_RS17070 3602938..3604371 - 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -
G5C52_RS17075 3604488..3605219 - 732 WP_137048235.1 MurR/RpiR family transcriptional regulator -
G5C52_RS17080 3605486..3606145 + 660 WP_003863433.1 hemolysin III family protein -
G5C52_RS17085 3606231..3607211 - 981 WP_022649306.1 tRNA-modifying protein YgfZ -
G5C52_RS17090 3607506..3607772 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
G5C52_RS17095 3607753..3608163 + 411 WP_022649305.1 protein YgfX Toxin
G5C52_RS17100 3608165..3608686 - 522 WP_059294460.1 flavodoxin FldB -
G5C52_RS17105 3608788..3609684 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
G5C52_RS17110 3609713..3610426 + 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G5C52_RS17115 3610432..3612165 + 1734 WP_023314793.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T150863 WP_022649305.1 NZ_CP049188:3607753-3608163 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T150863 NZ_CP065056:c1312733-1312473 [Streptococcus equi subsp. zooepidemicus]
ATGTATCATATAGAGTATTCTAAAAAGGCTCAAAAGCAGATTAAGAAACTAGATAAGCAAATTCAGAGGTTGCTATTTGC
TTGGATTGATAAGCATTTAGAGGGAACAGATAACCCACGCGCAAATGGCAAAGGTTTGACCGGAAATCATGCTAATGAGT
GGCGTTATCGTATTGGTGATTATAGGCTTATTTGTGATATTCAAGATGATAAGATGGTTGTTTTAGCGCTTGAGTTTGGG
CATCGTAAAGATATTTACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT150863 WP_003863437.1 NZ_CP049188:3607506-3607772 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT150863 NZ_CP065056:c1312956-1312735 [Streptococcus equi subsp. zooepidemicus]
ATGAGTACAGTTACTATCAGATTAAATCAAGAAGAAGAAATATTTTTCAAAAGTTACGCCCAACTCACAGGGCAAAGTTT
ATCAAGTCTATTTAAAAAAGCCCTTGAGCGGGATATTGAAGATGAGTATGATTTAAAACTCTATCATCAAGCCTATGCTG
AATATAAAGCAGACCCTGAGACAATTAGCCATGCGGATTTTAAGAAAGAGCTAGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References