Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4327083..4327701 Replicon chromosome
Accession NZ_CP049185
Organism Shigella sonnei strain 19.0821.3486

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G6O60_RS21985 Protein ID WP_001291435.1
Coordinates 4327083..4327301 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H8V4S8
Locus tag G6O60_RS21990 Protein ID WP_000344804.1
Coordinates 4327327..4327701 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O60_RS21950 (4322375) 4322375..4322947 + 573 WP_000779812.1 YbaY family lipoprotein -
G6O60_RS21955 (4322978) 4322978..4323289 - 312 WP_000409911.1 MGMT family protein -
G6O60_RS21965 (4323668) 4323668..4324021 + 354 WP_000878140.1 DUF1428 domain-containing protein -
G6O60_RS21970 (4324063) 4324063..4325611 - 1549 Protein_4280 cyclic-guanylate-specific phosphodiesterase PdeB -
G6O60_RS21975 (4325775) 4325775..4326245 - 471 WP_000136192.1 YlaC family protein -
G6O60_RS21980 (4326361) 4326361..4326912 - 552 WP_000102564.1 maltose O-acetyltransferase -
G6O60_RS21985 (4327083) 4327083..4327301 - 219 WP_001291435.1 HHA domain-containing protein Toxin
G6O60_RS21990 (4327327) 4327327..4327701 - 375 WP_000344804.1 Hha toxicity modulator TomB Antitoxin
G6O60_RS21995 (4328247) 4328247..4331396 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
G6O60_RS22000 (4331419) 4331419..4332612 - 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T150852 WP_001291435.1 NZ_CP049185:c4327301-4327083 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T150852 NZ_CP065047:c5026030-5025638 [Mycobacterium kubicae]
ATGGCGGCCATCTACCTGGACTCGTCCGCAATCGTCAAGCTTGCAGTTCGTGAGCCAGAGTCGGATGCGCTGCGTCGCTA
CCTTCGCACCCGGCTGCCGCGGGTGTCGAGTGCCCTTGCGCGGACGGAGGTCATGCGGGCTCTGCTCCACAAGGGTGAAT
CAGCCCGAAGAGCCGGACGCCGGGCGCTCGCGAGCCTAGACCTACTACGCATCGACAACCGATTGCTCGATCTTGCTGGT
GGGCTGCTGCCAATCGAGCTACGCACCCTCGATGCAATTCACCTGGCGACTGCCCAGCGGCTCGGCATGGATCTTGGCCG
GTTGTGCACTTACGACGACCGCATGCGCGACGCCGCCGAGGCGCTCGGCATGGCAGTGATTGCCCCGTCTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14615.43 Da        Isoelectric Point: 4.6232

>AT150852 WP_000344804.1 NZ_CP049185:c4327701-4327327 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIETFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT150852 NZ_CP065047:c5026305-5026030 [Mycobacterium kubicae]
ATGTCTACGGTGGGCGTTCGTGAGCTGCGGCAGCGGGCCAGCGAACTCCTCCGTCGGGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGTGGTCGGCCTATCGCCCTTCTCTCGCCGATGCCGGAGGGCGGTCCGTACCAGCAGATGCTGGCAAGCG
GCGGGATCGAACGTGCGACGCTTGACTTTGATGACCTTCCCGAGCCGGTCCGACTCAAAACGGGTATCGAGCTGCCGTCC
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H8V4S8

References