Detailed information of TA system TA150831

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 11833..12097
• Replicon: plasmid pL4094
• Accession: NZ_CP049180
• Organism: Shigella sonnei strain L4094

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: U9Z417
• Locus tag: G6O64_RS24815
• Protein ID: WP_001387489.1
• Coordinates: 11833..11985 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	12035..12097 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6O64_RS24785 (7134)	7134..9302	+	2169	WP_001774191.1	DotA/TraY family protein	-
G6O64_RS24790 (9376)	9376..10026	+	651	WP_001178506.1	plasmid IncI1-type surface exclusion protein ExcA	-
G6O64_RS24795 (10098)	10098..10307	-	210	WP_000062603.1	HEAT repeat domain-containing protein	-
G6O64_RS24800 (10673)	10673..10849	+	177	WP_001054898.1	hypothetical protein	-
G6O64_RS25330 (10914)	10914..11009	-	96	WP_000609148.1	DinQ-like type I toxin DqlB	-
G6O64_RS24810 (11510)	11510..11761	+	252	WP_001291964.1	hypothetical protein	-
G6O64_RS24815 (11833)	11833..11985	-	153	WP_001387489.1	Hok/Gef family protein	Toxin
- (12035)	12035..12097	+	63	NuclAT_0	-	Antitoxin
- (12035)	12035..12097	+	63	NuclAT_0	-	Antitoxin
- (12035)	12035..12097	+	63	NuclAT_0	-	Antitoxin
- (12035)	12035..12097	+	63	NuclAT_0	-	Antitoxin
G6O64_RS24820 (12612)	12612..13391	+	780	WP_275450201.1	protein FinQ	-
G6O64_RS24825 (13698)	13698..14906	+	1209	WP_107372241.1	IncI1-type conjugal transfer protein TrbA	-
G6O64_RS24830 (14925)	14925..15995	+	1071	WP_000151590.1	IncI1-type conjugal transfer protein TrbB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaCTX-M-3	-	1..86136	86136

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5761.10 Da
• Isoelectric Point: 8.7948

>T150831 WP_001387489.1 NZ_CP049180:c11985-11833 [Shigella sonnei]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T150831 NZ_CP065042:446874-447134 [Photobacterium damselae subsp. damselae]
ATGACCGTTTTGAGTTTTTCTGAAGTTCGAGGCAATTTTAAAAAAGTATGCGATCAAGTCGTTGATGATTGCGATGCAGT
AGTTATCCATCGACGTGATGCAGATAATGTCGTGCTTATGTCTGAATCTGAGTTTAATAGCTGGAAGGAAACGATGTATC
TCATGTCTAATCCTGTAAATGCTGCAAACTTACTTGAATCAATAAAACAAGCTGAGTGTGGTAATGTACAGACACATGAG
CTACTAAGCCATGATGATTAA

Antitoxin

Nucleotide

• Length: 63 bp

>AT150831 NZ_CP049180:12035-12097 [Shigella sonnei]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: U9Z417

Antitoxin