Detailed information of TA system TA150786

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 21099..21363
• Replicon: plasmid p7111-69
• Accession: NZ_CP049176
• Organism: Shigella sonnei strain 7111.69

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: U9Z417
• Locus tag: G6O62_RS24705
• Protein ID: WP_001387489.1
• Coordinates: 21099..21251 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	21301..21363 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6O62_RS24675 (16400)	16400..18568	+	2169	WP_001774191.1	DotA/TraY family protein	-
G6O62_RS24680 (18642)	18642..19292	+	651	WP_001178506.1	plasmid IncI1-type surface exclusion protein ExcA	-
G6O62_RS24685 (19364)	19364..19573	-	210	WP_000062603.1	HEAT repeat domain-containing protein	-
G6O62_RS24690 (19939)	19939..20115	+	177	WP_001054898.1	hypothetical protein	-
G6O62_RS24695 (20180)	20180..20476	-	297	WP_001275298.1	DinQ-like type I toxin DqlB	-
G6O62_RS24700 (20776)	20776..21027	+	252	WP_001291964.1	hypothetical protein	-
G6O62_RS24705 (21099)	21099..21251	-	153	WP_001387489.1	Hok/Gef family protein	Toxin
- (21301)	21301..21363	+	63	NuclAT_0	-	Antitoxin
- (21301)	21301..21363	+	63	NuclAT_0	-	Antitoxin
- (21301)	21301..21363	+	63	NuclAT_0	-	Antitoxin
- (21301)	21301..21363	+	63	NuclAT_0	-	Antitoxin
G6O62_RS24710 (21572)	21572..22657	+	1086	WP_000080543.1	protein finQ	-
G6O62_RS24715 (22964)	22964..24172	+	1209	WP_107372241.1	IncI1-type conjugal transfer protein TrbA	-
G6O62_RS24720 (24191)	24191..25261	+	1071	WP_000151590.1	IncI1-type conjugal transfer protein TrbB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaCTX-M-3	-	1..86143	86143

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5761.10 Da
• Isoelectric Point: 8.7948

>T150786 WP_001387489.1 NZ_CP049176:c21251-21099 [Shigella sonnei]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T150786 NZ_CP065032:c3546011-3545655 [Serratia sp. CMO1]
ATGATCTTTTTGACCGCAGAGGATATTGCGGAATTCAACGCTGAAATTGTGCCTCACGGCCGCCAGGAAGGCAGCAAGGT
TGAGGCTGTAGCCAACCGCGTGCTCAATGCTTACCACTATGAGAACGTCACCGACGTTTACCGTTTGGCCGCGCTCTATC
TCATCGCCATCAGCCACGGTCACATTTTTCTTGATGGCAACAAACGTACGGCCTTCCAAAGCATGGCGCTATTTCTCGGT
ATTAATGGCATTGCACTGCGGGAAGACGCAGAACTGGTCGAAATTACGGTTGAAGCAGCTCAAGGCCGCCTCAACGTAGA
ACAAGCCGCTGAACACTTACGCCGGCTAACCGAATAA

Antitoxin

Nucleotide

• Length: 63 bp

>AT150786 NZ_CP049176:21301-21363 [Shigella sonnei]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: U9Z417

Antitoxin