Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1463206..1463860 Replicon chromosome
Accession NZ_CP049167
Organism Shigella sonnei strain 09163633

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag G6O57_RS07285 Protein ID WP_000244777.1
Coordinates 1463453..1463860 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag G6O57_RS07280 Protein ID WP_000354046.1
Coordinates 1463206..1463472 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6O57_RS07255 (1458375) 1458375..1459118 + 744 WP_000951937.1 SDR family oxidoreductase -
G6O57_RS07260 (1459175) 1459175..1460608 - 1434 WP_005137189.1 6-phospho-beta-glucosidase BglA -
G6O57_RS07265 (1460653) 1460653..1460964 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
G6O57_RS07270 (1461128) 1461128..1461787 + 660 WP_000250274.1 hemolysin III family protein -
G6O57_RS07275 (1461983) 1461983..1462963 - 981 WP_000886060.1 tRNA-modifying protein YgfZ -
G6O57_RS07280 (1463206) 1463206..1463472 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
G6O57_RS07285 (1463453) 1463453..1463860 + 408 WP_000244777.1 protein YgfX Toxin
G6O57_RS07290 (1463900) 1463900..1464421 - 522 WP_001055874.1 flavodoxin FldB -
G6O57_RS07295 (1464533) 1464533..1465429 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
G6O57_RS07300 (1465454) 1465454..1466164 + 711 WP_000715206.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
G6O57_RS07305 (1466170) 1466170..1467903 + 1734 WP_000813167.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T150687 WP_000244777.1 NZ_CP049167:1463453-1463860 [Shigella sonnei]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T150687 NZ_CP064908:c2871197-2870853 [Synechococcus sp. CBW1107]
GTGAGCGCCTTCAAGAGGTACACGGTGGTGCGAGTTCCGTTCCCATTCACTGATCGCCAGGCCCAGAAGCAGCGGCCGGC
GTTGGTGCTCTCACAGCTCTGCTTTCAGCAAAGCTGTGGCCATCTGCTGCTGGCGATGATCACATCAGCGCGGCAATCCT
CCTGGCCCCTCGATTGGCCCCTTGAAGATCTCAAGGCCGCGGGCCTGCCCCAACCCTGCCTGGTGCGCTTCAAGCTGTTC
ACCATTGATGAGCGGCTGGTGTTGGGTGGCCTGGGCGCTCTGGCCGCCGCCGATTGCGCCGGTGTGTCGGCCCAGCTGGG
CAAGCTGCTGCCCTCCGGGACCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT150687 WP_000354046.1 NZ_CP049167:1463206-1463472 [Shigella sonnei]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT150687 NZ_CP064908:c2871418-2871194 [Synechococcus sp. CBW1107]
ATGGAAGTCGCCACACTCACCGCCAAAGGACAGGTCACGGTGCCGAAGGCGGTGCGTGAGGCCCTGGGATTGCGGCAGGG
CGACCAGCTCAGTTGGGAACTGGAGGATGGCTCGGTGCGCGTGCGGGCGGTGACGCCGTTGGATCTGGCCTATCTCCGGG
GGCTGGAGAGCAGCCTTAGCGAGTGGAGTAGCCCGGCGGATGAGGAGGCGTTCCGCGAACTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References