Detailed information of TA system TA150654

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 1465228..1465766
• Replicon: plasmid pSBC1_2
• Accession: NZ_CP049158
• Organism: Caballeronia sp. SBC1

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: SBC1_RS33380
• Protein ID: WP_165104579.1
• Coordinates: 1465228..1465527 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SBC1_RS33385
• Protein ID: WP_165104580.1
• Coordinates: 1465524..1465766 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBC1_RS33360	1460574..1461290	+	717	WP_165104575.1	2Fe-2S iron-sulfur cluster binding domain-containing protein	-
SBC1_RS33365	1461300..1462289	+	990	WP_165104576.1	xanthine dehydrogenase family protein subunit M	-
SBC1_RS33370	1462286..1464514	+	2229	WP_165104577.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
SBC1_RS33375	1464634..1465221	+	588	WP_165104578.1	nucleotidyltransferase family protein	-
SBC1_RS33380	1465228..1465527	-	300	WP_165104579.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SBC1_RS33385	1465524..1465766	-	243	WP_165104580.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
SBC1_RS33390	1465948..1466643	-	696	WP_165104581.1	glycosyltransferase	-
SBC1_RS33395	1467058..1467510	-	453	WP_165104582.1	DUF2442 domain-containing protein	-
SBC1_RS33400	1467507..1467926	-	420	WP_165104583.1	DUF4160 domain-containing protein	-
SBC1_RS33405	1468178..1468675	+	498	WP_165104584.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	adeG / gnd	1..1826371	1826371

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-71)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11569.43 Da
• Isoelectric Point: 10.2789

>T150654 WP_165104579.1 NZ_CP049158:c1465527-1465228 [Caballeronia sp. SBC1]
MTYKLRFKLNAEKEWRKLDAETRRQFAKKLDLRLENPKVPASRLHGMKDCYKIKLRTRGYRLVYQVQDEIVTVVVIAVGK
RDGGVVHDAAEERAAEEPQ

Nucleotide

• Length: 300 bp

>T150654 NZ_CP064860:1325684-1325947 [Companilactobacillus futsaii]
ATGTCTTATTCAATAAAATTTAAAAATTCTTCTAAAAATGATTTAAAAAAGATAAAGAATAGTCCATTTTGTAAGAAATT
TGACGAAATAATTAAAAAGTTGTCAGTAAATCCATATGATCCATCAGATAACTTTGAAAAATTGTTTCCACCAGAAGATA
AACTTTATTCTAGAAGATTGAATATTCAACATCGTATTGTATATTCAATTGATGAGGAGAAACAAATAGTACATATTTAT
TCAGCGTGGAATCATTACGCGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8808.02 Da
• Isoelectric Point: 4.3210

>AT150654 WP_165104580.1 NZ_CP049158:c1465766-1465524 [Caballeronia sp. SBC1]
MEAIHATQSVGISELKLNPTAVIESADGGAVAILNRNKPVAYLLPAEQYEALLDRLEDFELAEIVRARQNEPLVEVDIHK

Nucleotide

• Length: 243 bp

>AT150654 NZ_CP064860:1325418-1325681 [Companilactobacillus futsaii]
ATGCAAAGAATGACTAATCCTACTCAAGCAAGAAAAGACTTTTATAAAATTATTAAATCAGTTAATGAAAATTCTACTCC
TATAGAGATAAATGGACGAACAGAAGATGACAGTGCAGTTATTATGAGTGCTAAAGATTATAGATCATTACAGGAAACAC
TCTACTTAATGAATGACGGTACGCTTAATAAAGTTCATAAAGCTATTGCTGACGATTCTGGTGAGACTGATATAACAAAT
GGCGTTGATTGGGATAAAATTTAG