Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 172762..173345 Replicon plasmid pSBC1_2
Accession NZ_CP049158
Organism Caballeronia sp. SBC1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SBC1_RS27665 Protein ID WP_165102153.1
Coordinates 173091..173345 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag SBC1_RS27660 Protein ID WP_165102150.1
Coordinates 172762..173094 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBC1_RS27635 168057..168857 - 801 WP_165097072.1 IS21-like element helper ATPase IstB -
SBC1_RS27640 168835..170322 - 1488 WP_165097075.1 IS21 family transposase -
SBC1_RS27645 170315..170713 - 399 WP_147408238.1 hypothetical protein -
SBC1_RS27650 170685..171185 - 501 WP_165097078.1 hypothetical protein -
SBC1_RS27655 171616..172647 + 1032 WP_165102147.1 site-specific tyrosine recombinase XerC -
SBC1_RS27660 172762..173094 - 333 WP_165102150.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SBC1_RS27665 173091..173345 - 255 WP_165102153.1 type II toxin-antitoxin system HicA family toxin Toxin
SBC1_RS27670 174219..174860 + 642 WP_165104850.1 RHS repeat-associated core domain-containing protein -
SBC1_RS27675 174867..175388 + 522 WP_165102165.1 hypothetical protein -
SBC1_RS27680 175678..176130 + 453 WP_165102168.1 RHS repeat-associated core domain-containing protein -
SBC1_RS27685 176484..176705 - 222 WP_165102171.1 type I toxin-antitoxin system SymE family toxin -
SBC1_RS27690 176811..177119 - 309 WP_165102174.1 helix-turn-helix domain-containing protein -
SBC1_RS27695 177336..177557 + 222 WP_031362537.1 YdcH family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - adeG / gnd 1..1826371 1826371


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-75)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9433.94 Da        Isoelectric Point: 10.9436

>T150653 WP_165102153.1 NZ_CP049158:c173345-173091 [Caballeronia sp. SBC1]
MKRAHTKTLELIFARPVSANVRWADIEALFLELGATITEREGSRIAVVLFGQVQVYHRPHPRPTTDKGAIASVRKWLESN
GVKP

Download         Length: 255 bp

>T150653 NZ_CP064859:c415786-415496 [Vibrio europaeus]
ATGACCTATAAACTTGACTTTAAAAAGAGCGCACTTAAAGAATGGAAAAAACTAGGTGCGACGTTGCAACAGCAATTTAA
GAAAAAGTTGATTGAGCGCTTGGAAACCCCCCATGTTCAAGCATCAAAGCTCACAGGGGCTGACAACCTGTATAAGATAA
AACTTCGCCAATCCGGTTACCGATTAGTCTATAAGGTCGAAGACGATGTTATCACTGTTACTGTACTAGCCGTTGGTAAA
CGCGAACGTAGTGATGTTTACCGCAAGGCGATGCAACGTTTAGACAACTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12163.65 Da        Isoelectric Point: 4.5594

>AT150653 WP_165102150.1 NZ_CP049158:c173094-172762 [Caballeronia sp. SBC1]
MNILSIDNYRAVVTYDPDTDMLRGEFLGLNGGADFYASDIPTLKTEGAKSLAVFLDVCRENGIDPVRHFSGRFNARIDPE
LHARAVETAAAEGISLNQLIERAIEHEVRT

Download         Length: 333 bp

>AT150653 NZ_CP064859:c416024-415776 [Vibrio europaeus]
ATGGCCACAAGAATTTTAGCTGACGTCGCTGCAAGTATTACAGAATTAAAAGCTAACCCTATGAAAGTTGCAACTAGTGG
TTGTGGCGAGCCGGTTGCTGTTCTGAATCGAAATGAGCCTGCTTTTTATTGCGTCCCTGCGCAAGCCTATGAAACGCTAG
TGGATAGACTCGAAGATCTTGAGTTGCTTGCGATAGCCAAAGAGCGCGAATTAGAAGAAAGTATTTCGGTAAATATAGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References