Detailed information of TA system TA150649

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2774958..2775580
• Replicon: chromosome
• Accession: NZ_CP049156
• Organism: Caballeronia sp. SBC1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SBC1_RS12265
• Protein ID: WP_165987787.1
• Coordinates: 2775197..2775580 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: SBC1_RS12260
• Protein ID: WP_165988832.1
• Coordinates: 2774958..2775200 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBC1_RS12240	2771336..2771575	-	240	WP_165987779.1	hypothetical protein	-
SBC1_RS12245	2771568..2771921	-	354	WP_165987781.1	S24 family peptidase	-
SBC1_RS12250	2771914..2772531	-	618	WP_165987783.1	hypothetical protein	-
SBC1_RS12255	2772979..2774355	-	1377	WP_165987785.1	integrase family protein	-
SBC1_RS12260	2774958..2775200	+	243	WP_165988832.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SBC1_RS12265	2775197..2775580	+	384	WP_165987787.1	type II toxin-antitoxin system VapC family toxin	Toxin
SBC1_RS12270	2775917..2776660	+	744	WP_165092196.1	FadR family transcriptional regulator	-
SBC1_RS12275	2777081..2777311	+	231	Protein_2406	MFS transporter	-
SBC1_RS12280	2777472..2778830	+	1359	WP_165987789.1	glucarate dehydratase	-
SBC1_RS12285	2778908..2779825	+	918	WP_165092198.1	5-dehydro-4-deoxyglucarate dehydratase	-
SBC1_RS12290	2779907..2780497	-	591	WP_165987791.1	LUD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Antitoxin

• SpoVT-AbrB domain (7-44)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14105.05 Da
• Isoelectric Point: 7.4674

>T150649 WP_165987787.1 NZ_CP049156:2775197-2775580 [Caballeronia sp. SBC1]
VNYLLDTNAVIALMKGHSGFLARLRQHQPRDFAMPSIVAHELYFGAYKSRHAAGNLRRVEALQFEILDFDPEDTRRAGEV
RAQLASAGTPIGPYDVLIAGQALARSLTLVTHNMREFQRVSGLSVED

Nucleotide

• Length: 384 bp

>T150649 NZ_CP064855:c2872103-2871867 [Erwinia amylovora]
ATAAGCTATGAACTGCTCTTCGATCCCTGGGCCTTAAAAGAGTGGAAAAAACTGGGCGCAACGGTTCGGGAACAGTTCAA
AAAGAAACTGGCGGAAGTGCTGGTAAACCTGCAGGTGGAATCAGCCAGGCTGAGAGATCACCCGGACTGCTGCAAAATAA
AGCTGAAATCATCGGGTTATCGTCTGGTATATCAGGTTCAGGATGAACAGCTGGTAATGTTGGTTATAAGCGTTTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9230.35 Da
• Isoelectric Point: 4.5024

>AT150649 WP_165988832.1 NZ_CP049156:2774958-2775200 [Caballeronia sp. SBC1]
MDTAKVFWSGRSQAVRLPKEFRLDADEVRVRRHGRAIILEPIASDWAWLDSVVGPIDDDFAEAAQEKLSEQDRPDLDFFK

Nucleotide

• Length: 243 bp

>AT150649 NZ_CP064855:c2872320-2872093 [Erwinia amylovora]
GTGCGGCTGGATGACAAACTGAAAAGCAAAGCCTGTGCAGTTCTGGATGAACTGGATGTATCGCCAACGGAGGCGGTCCG
GCTGTTGTTCCAGTATATAGCGGAAAATGAGCGCCTACCGCTGAAAGCGCTGACGGTAAGTGATGAAAAAGACGCGCTGC
TGAAAACGGTTCGCGAAAGGCTGGCATCGCTACAGAAGGGAATAAAGGTAACGCTGGATAAGCTATGA