150571

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3373494..3374112 Replicon chromosome
Accession NZ_CP049112
Organism Escherichia coli strain WF5-5-T2

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag G6R06_RS16480 Protein ID WP_001291435.1
Coordinates 3373894..3374112 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag G6R06_RS16475 Protein ID WP_000344800.1
Coordinates 3373494..3373868 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6R06_RS16465 (3368583) 3368583..3369776 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
G6R06_RS16470 (3369799) 3369799..3372948 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
G6R06_RS16475 (3373494) 3373494..3373868 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
G6R06_RS16480 (3373894) 3373894..3374112 + 219 WP_001291435.1 HHA domain-containing protein Toxin
G6R06_RS16485 (3374284) 3374284..3374835 + 552 WP_000102564.1 maltose O-acetyltransferase -
G6R06_RS16490 (3374951) 3374951..3375421 + 471 WP_000136192.1 YlaC family protein -
G6R06_RS16495 (3375585) 3375585..3377135 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
G6R06_RS16500 (3377177) 3377177..3377530 - 354 WP_000878140.1 DUF1428 domain-containing protein -
G6R06_RS16510 (3377909) 3377909..3378220 + 312 WP_000409911.1 MGMT family protein -
G6R06_RS16515 (3378251) 3378251..3378823 - 573 WP_000779842.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T150571 WP_001291435.1 NZ_CP049112:3373894-3374112 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T150571 NZ_CP064825:53260-53382 [Escherichia coli UTI89]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTGTTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT150571 WP_000344800.1 NZ_CP049112:3373494-3373868 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT150571 NZ_CP064825:53024-53257 [Escherichia coli UTI89]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References