Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1981117..1981756 Replicon chromosome
Accession NZ_CP049088
Organism Glaesserella parasuis strain sHPS7

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag G5C59_RS09730 Protein ID WP_075630966.1
Coordinates 1981421..1981756 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G5C59_RS09725 Protein ID WP_164681833.1
Coordinates 1981117..1981413 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G5C59_RS09705 1977419..1978022 - 604 Protein_1886 transposase -
G5C59_RS09710 1978411..1978963 + 553 Protein_1887 IS5 family transposase -
G5C59_RS09715 1978990..1979954 - 965 Protein_1888 IS3 family transposase -
G5C59_RS09720 1980055..1981044 - 990 WP_035524355.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
G5C59_RS09725 1981117..1981413 - 297 WP_164681833.1 putative addiction module antidote protein Antitoxin
G5C59_RS09730 1981421..1981756 - 336 WP_075630966.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G5C59_RS09735 1981915..1982319 + 405 WP_021110905.1 DNA polymerase III subunit psi -
G5C59_RS09740 1982434..1982778 + 345 WP_035524358.1 hypothetical protein -
G5C59_RS09745 1982841..1983185 + 345 WP_164681776.1 oligoendopeptidase F family protein -
G5C59_RS09750 1983202..1983555 + 354 WP_164681777.1 hypothetical protein -
G5C59_RS09755 1983616..1983780 + 165 WP_164681778.1 hypothetical protein -
G5C59_RS09760 1983872..1984615 + 744 Protein_1897 transposase -
G5C59_RS09765 1984804..1984989 - 186 WP_005713975.1 zf-HC2 domain-containing protein -
G5C59_RS09770 1984986..1985558 - 573 WP_021116087.1 sigma-70 family RNA polymerase sigma factor -
G5C59_RS09775 1985699..1986028 + 330 WP_021110897.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1978411..1990181 11770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(7-103)

Antitoxin

Uncharacterized protein HI1420

(9-91)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12166.89 Da        Isoelectric Point: 9.5918

>T150452 WP_075630966.1 NZ_CP049088:c1981756-1981421 [Glaesserella parasuis]
MSGIINQIIITDNFSKWLDGLKNPIAKATVARRIKNTVKGNFDDHKALAGTGGLYEMRIATGAGYRIYYAQQGDVIYILL
QGGDKSTLQADIEKAKALWAELKQTGGSNEY

Download         Length: 336 bp

>T150452 NZ_CP064682:c2082946-2082692 [Escherichia coli K-12]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10948.49 Da        Isoelectric Point: 4.8951

>AT150452 WP_164681833.1 NZ_CP049088:c1981413-1981117 [Glaesserella parasuis]
MAEKHGLRPFDVAEFLDNEETIQAYLAEVLKEGDQDEFLEALNDVARARGIAELAKQTGLGRESLYKTLSKGSKPRFETI
QKILGAFNLVLIPQIKNS

Download         Length: 297 bp

>AT150452 NZ_CP064682:c2083194-2082943 [Escherichia coli K-12]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References