Detailed information of TA system TA150437

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4376943..4377763
• Replicon: chromosome
• Accession: NZ_CP049085
• Organism: Escherichia coli strain p4A

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: G6P91_RS21510
• Protein ID: WP_001054379.1
• Coordinates: 4376943..4377200 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: G6P91_RS21515
• Protein ID: WP_000123957.1
• Coordinates: 4377212..4377763 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6P91_RS21490	4372490..4373470	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
G6P91_RS21495	4374053..4375159	-	1107	Protein_4219	DNA helicase	-
G6P91_RS21500	4375222..4376369	+	1148	WP_085949154.1	IS3-like element ISEc52 family transposase	-
G6P91_RS21505	4376402..4376566	+	165	Protein_4221	GNAT family N-acetyltransferase	-
G6P91_RS21510	4376943..4377200	+	258	WP_001054379.1	YjhX family toxin	Toxin
G6P91_RS21515	4377212..4377763	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
G6P91_RS21520	4377815..4378561	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
G6P91_RS21525	4378689..4378949	+	261	WP_000077645.1	hypothetical protein	-
G6P91_RS21530	4378987..4379103	+	117	Protein_4226	VOC family protein	-
G6P91_RS21535	4379348..4380469	+	1122	WP_112032097.1	M42 family metallopeptidase	-
G6P91_RS21540	4380466..4380744	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
G6P91_RS21545	4380756..4382069	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimE	4365564..4385984	20420

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T150437 WP_001054379.1 NZ_CP049085:4376943-4377200 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T150437 NZ_CP064681:c4523876-4523619 [Escherichia coli K-12]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT150437 WP_000123957.1 NZ_CP049085:4377212-4377763 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT150437 NZ_CP064681:c4523607-4523062 [Escherichia coli K-12]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: B6I030