Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 6424376..6425007 Replicon chromosome
Accession NZ_CP049045
Organism Pseudomonas sp. BIOMIG1BAC

Toxin (Protein)


Gene name vapC Uniprot ID A0A6G7A6F6
Locus tag ATY02_RS29805 Protein ID WP_068588741.1
Coordinates 6424376..6424774 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G7A756
Locus tag ATY02_RS29810 Protein ID WP_068588739.1
Coordinates 6424774..6425007 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATY02_RS29780 6419438..6419803 + 366 WP_031320450.1 hypothetical protein -
ATY02_RS29785 6419812..6420393 - 582 WP_068588876.1 hypothetical protein -
ATY02_RS29790 6420555..6422600 - 2046 WP_068588878.1 c-type cytochrome -
ATY02_RS29795 6422816..6423481 - 666 WP_068588881.1 ArsR family transcriptional regulator -
ATY02_RS29800 6423590..6424093 + 504 WP_068588884.1 DUF2938 domain-containing protein -
ATY02_RS29805 6424376..6424774 - 399 WP_068588741.1 tRNA(fMet)-specific endonuclease VapC Toxin
ATY02_RS29810 6424774..6425007 - 234 WP_068588739.1 antitoxin Antitoxin
ATY02_RS29815 6425184..6425765 + 582 WP_068588736.1 DedA family protein -
ATY02_RS29820 6425886..6427133 + 1248 WP_068588734.1 aspartate aminotransferase family protein -
ATY02_RS29825 6427159..6427743 - 585 WP_068588731.1 hypothetical protein -
ATY02_RS29830 6427748..6428191 - 444 WP_068588728.1 DUF3592 domain-containing protein -
ATY02_RS29835 6428339..6429169 - 831 WP_068588724.1 amidohydrolase family protein -
ATY02_RS29840 6429330..6429725 + 396 WP_068588722.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14966.26 Da        Isoelectric Point: 8.4866

>T150327 WP_068588741.1 NZ_CP049045:c6424774-6424376 [Pseudomonas sp. BIOMIG1BAC]
MFKYMLDTNICIFTIKNKPQQVREAFSRNQGRLCISSITLMELIYGAEKSAVPEKNLGRVESFVARLQVLDYDDNAAIHS
GQLQAELVQKGKRIGPYDQLIAGHARSLGLTLVTNNLREFERVPGLRVEDWV

Download         Length: 399 bp

>T150327 NZ_CP064674:c4528135-4527761 [Salmonella sp. SJTUF14076]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAGAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAGCGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
TAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8732.69 Da        Isoelectric Point: 4.2092

>AT150327 WP_068588739.1 NZ_CP049045:c6425007-6424774 [Pseudomonas sp. BIOMIG1BAC]
METGSVFKSNRSQAIRMPKAVALPDDVTRVDIVAIGRTRIITPAGESWDSWFDEQDSVSADFMTEREQPAEQVREEF

Download         Length: 234 bp

>AT150327 NZ_CP064674:c4528377-4528135 [Salmonella sp. SJTUF14076]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGATGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G7A6F6

Antitoxin

Source ID Structure
AlphaFold DB A0A6G7A756

References