Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4088240..4088859 Replicon chromosome
Accession NZ_CP049045
Organism Pseudomonas sp. BIOMIG1BAC

Toxin (Protein)


Gene name hicA Uniprot ID A0A6G7A0S3
Locus tag ATY02_RS18935 Protein ID WP_068588599.1
Coordinates 4088240..4088422 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A6G7A272
Locus tag ATY02_RS18940 Protein ID WP_068588591.1
Coordinates 4088458..4088859 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATY02_RS18920 4083749..4084933 - 1185 WP_068588771.1 hypothetical protein -
ATY02_RS18925 4084930..4086072 - 1143 WP_068588775.1 hypothetical protein -
ATY02_RS18930 4086549..4087710 - 1162 Protein_3741 IS3 family transposase -
ATY02_RS18935 4088240..4088422 + 183 WP_068588599.1 type II toxin-antitoxin system HicA family toxin Toxin
ATY02_RS18940 4088458..4088859 + 402 WP_068588591.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ATY02_RS18945 4089040..4089363 - 324 WP_068588594.1 hypothetical protein -
ATY02_RS18950 4089815..4091218 - 1404 WP_068588596.1 PLP-dependent aminotransferase family protein -
ATY02_RS18955 4091306..4091752 + 447 WP_164823693.1 GNAT family N-acetyltransferase -
ATY02_RS18960 4091749..4092369 + 621 WP_068588565.1 NAD(P)H-dependent oxidoreductase -
ATY02_RS18965 4092397..4092828 + 432 WP_068588568.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4077419..4089363 11944


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6899.12 Da        Isoelectric Point: 11.2684

>T150326 WP_068588599.1 NZ_CP049045:4088240-4088422 [Pseudomonas sp. BIOMIG1BAC]
VQSRQLIKELEAAGWILDRITGSHHLFKHPYRPNTVPVPHPKKDLPRGTVRAIRKLAELI

Download         Length: 183 bp

>T150326 NZ_CP064674:c4107564-4107280 [Salmonella sp. SJTUF14076]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14550.58 Da        Isoelectric Point: 4.8783

>AT150326 WP_068588591.1 NZ_CP049045:4088458-4088859 [Pseudomonas sp. BIOMIG1BAC]
MQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFESAYSAAIEIAHVMLEELARAGQAIPLPSPTSKHRVNPDFAGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQQIDRFVREHNIKSRSSFLADAALEKLGR

Download         Length: 402 bp

>AT150326 NZ_CP064674:c4107796-4107554 [Salmonella sp. SJTUF14076]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTACGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G7A0S3

Antitoxin

Source ID Structure
AlphaFold DB A0A6G7A272

References