Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3907635..3908857 Replicon chromosome
Accession NZ_CP049045
Organism Pseudomonas sp. BIOMIG1BAC

Toxin (Protein)


Gene name vapC Uniprot ID A0A6G7A0B4
Locus tag ATY02_RS18040 Protein ID WP_068583865.1
Coordinates 3907635..3908207 (-) Length 191 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U6ZMH2
Locus tag ATY02_RS18045 Protein ID WP_022639877.1
Coordinates 3908300..3908857 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATY02_RS18025 3902777..3904699 + 1923 WP_068583871.1 penicillin-binding protein 2 -
ATY02_RS18030 3904741..3907083 + 2343 WP_068583927.1 penicillin-binding protein 1A -
ATY02_RS18035 3907095..3907601 - 507 WP_068583868.1 N-acetyltransferase -
ATY02_RS18040 3907635..3908207 - 573 WP_068583865.1 HD domain-containing protein Toxin
ATY02_RS18045 3908300..3908857 - 558 WP_022639877.1 helix-turn-helix domain-containing protein Antitoxin
ATY02_RS18050 3909029..3909358 + 330 WP_022639876.1 low molecular weight protein tyrosine phosphatase family protein -
ATY02_RS18055 3909479..3910657 - 1179 WP_068583862.1 PrpF protein -
ATY02_RS18060 3910790..3911176 - 387 WP_068583860.1 DUF4180 domain-containing protein -
ATY02_RS18065 3911163..3912029 - 867 WP_164823689.1 alpha/beta fold hydrolase -
ATY02_RS18070 3912035..3912454 - 420 WP_068583854.1 helix-turn-helix domain-containing protein -
ATY02_RS18075 3912725..3913336 + 612 WP_068583852.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-168)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-49)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21548.15 Da        Isoelectric Point: 5.5614

>T150325 WP_068583865.1 NZ_CP049045:c3908207-3907635 [Pseudomonas sp. BIOMIG1BAC]
MNDQLLGGRLEFLRQAERLKDVLRSAHTSSGRQESTAEHSWRLCLMALLLEDQLGELDLLQVLKLCIVHDLGEALHGDIP
AVQQAAHPDKGQQEREDLQTLASCLDAPARQRLLALWDEYENASSAEARAVKALDKLETLVQHNQGRNPADFDYRFNLDY
GRRYTSATPLFRALREQIDHDTRRHIDAAG

Download         Length: 573 bp

>T150325 NZ_CP064674:3608573-3608800 [Salmonella sp. SJTUF14076]
ATGACCACCTATTACTCGCGCATCCCCAGCCTGCACCTTAAGGGCGACTGGCTGGCAGAAGCGGGATTTGATACCGGGGC
GAGCGTGACCGTGAAGATCTCCGAAGGGTGTTTGACTCTGATTGTGGAGACAGACGAAGTGAGGGATCTACGGAGGGAGC
TTTATCAGGTGAAAAAGTCGATGAAGCACATTAAGGCGGGGGTATATGATGTGGTGAACGGGAATTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20413.32 Da        Isoelectric Point: 7.0310

>AT150325 WP_022639877.1 NZ_CP049045:c3908857-3908300 [Pseudomonas sp. BIOMIG1BAC]
MSASLFTSPHLGLALRRWRLLHRVKQQHAAELFGVAQSSISRWENGQQAMEPSERAKLEQLLAANLSAAADQALARLVND
SPRAVHLVCDLTHRLLACSPTRAGEFGVPLSELLGQSLWGFCTEEIVRKERALDDLGWREVLAPPALEFFSGHNDSAIVP
IAASQCRWTRLNLSDGNAVRLVETL

Download         Length: 558 bp

>AT150325 NZ_CP064674:c3608790-3608565 [Salmonella sp. SJTUF14076]
TTCACCACATCATATACCCCCGCCTTAATGTGCTTCATCGACTTTTTCACCTGATAAAGCTCCCTCCGTAGATCCCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCTTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCAGGCTGGGGATGCGCGAGTAATAGGTGGTCATGTGGGTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G7A0B4

Antitoxin

Source ID Structure
AlphaFold DB A0A6G7A0D6

References