Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 1834811..1835324 Replicon chromosome
Accession NZ_CP049045
Organism Pseudomonas sp. BIOMIG1BAC

Toxin (Protein)


Gene name relE Uniprot ID A0A6G6ZW42
Locus tag ATY02_RS08515 Protein ID WP_068582176.1
Coordinates 1834811..1835095 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7X1FE57
Locus tag ATY02_RS08520 Protein ID WP_068582179.1
Coordinates 1835085..1835324 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATY02_RS08490 1829896..1830783 - 888 WP_068582163.1 dihydrodipicolinate synthase family protein -
ATY02_RS08495 1830817..1831599 - 783 WP_068582166.1 aldolase -
ATY02_RS08500 1831761..1832303 + 543 WP_068582169.1 XRE family transcriptional regulator -
ATY02_RS08505 1832442..1833461 - 1020 WP_068582209.1 DUF4917 family protein -
ATY02_RS08510 1833619..1834767 + 1149 WP_068582173.1 L-threonine dehydrogenase -
ATY02_RS08515 1834811..1835095 - 285 WP_068582176.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ATY02_RS08520 1835085..1835324 - 240 WP_068582179.1 ribbon-helix-helix protein, CopG family Antitoxin
ATY02_RS08525 1835521..1836261 + 741 WP_068582182.1 hypothetical protein -
ATY02_RS08530 1836272..1836997 + 726 WP_068582185.1 hypothetical protein -
ATY02_RS08535 1837001..1837444 + 444 WP_068582188.1 fosfomycin resistance glutathione transferase -
ATY02_RS08540 1837546..1838184 + 639 WP_068582191.1 LysE family translocator -
ATY02_RS08545 1838294..1839643 + 1350 WP_068582196.1 GGDEF domain-containing protein -
ATY02_RS08550 1839767..1840291 + 525 WP_068582198.1 DUF4142 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-41)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11100.77 Da        Isoelectric Point: 11.5026

>T150324 WP_068582176.1 NZ_CP049045:c1835095-1834811 [Pseudomonas sp. BIOMIG1BAC]
MHIEWLRTALKNLDDEARYIAQDNPEAAREFVQTLLTGIGHLARFPASGREGRLPGTREWVVPGWPYLIPYRVRGSRLQI
LRIFHTRRQPPQRW

Download         Length: 285 bp

>T150324 NZ_CP064674:3420574-3420792 [Salmonella sp. SJTUF14076]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCTGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8537.68 Da        Isoelectric Point: 4.4143

>AT150324 WP_068582179.1 NZ_CP049045:c1835324-1835085 [Pseudomonas sp. BIOMIG1BAC]
MSIMSLRLPDEMAETLALLAKATGRSKSFLAVDALREYLAREAWQIEEIQKALGEADAGDFASAEEVAAITGKWTGNAH

Download         Length: 240 bp

>AT150324 NZ_CP064674:3420172-3420546 [Salmonella sp. SJTUF14076]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6ZW42

Antitoxin

Source ID Structure
AlphaFold DB A0A7X1FE57

References