Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 778822..779516 Replicon chromosome
Accession NZ_CP049045
Organism Pseudomonas sp. BIOMIG1BAC

Toxin (Protein)


Gene name higB Uniprot ID U6ZZC4
Locus tag ATY02_RS03545 Protein ID WP_022640299.1
Coordinates 778822..779118 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6G6ZSS2
Locus tag ATY02_RS03550 Protein ID WP_068578624.1
Coordinates 779115..779516 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATY02_RS03510 774453..774998 - 546 WP_068578638.1 hypothetical protein -
ATY02_RS03515 774995..775249 - 255 WP_068578636.1 acyl carrier protein -
ATY02_RS03520 775259..775531 - 273 WP_068578634.1 acyl carrier protein -
ATY02_RS03525 775500..776321 - 822 WP_068578632.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
ATY02_RS03530 776297..777025 - 729 WP_068578630.1 beta-ketoacyl synthase chain length factor -
ATY02_RS03535 777337..778107 + 771 WP_068578628.1 ParA family protein -
ATY02_RS03540 778159..778593 - 435 WP_068578626.1 thioredoxin TrxC -
ATY02_RS03545 778822..779118 + 297 WP_022640299.1 type II toxin-antitoxin system HigB family toxin Toxin
ATY02_RS03550 779115..779516 + 402 WP_068578624.1 transcriptional regulator Antitoxin
ATY02_RS03555 779518..780981 - 1464 WP_068578621.1 YdiU family protein -
ATY02_RS03560 781051..784377 - 3327 WP_068578619.1 mechanosensitive channel MscK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-90)

Antitoxin

Antitoxin HigA

(15-133)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11566.41 Da        Isoelectric Point: 10.3534

>T150321 WP_022640299.1 NZ_CP049045:778822-779118 [Pseudomonas sp. BIOMIG1BAC]
MHIITAKRIWQAKEQWPQTARALDTWYRKAKGARPEDFSDMKALFPAVDKVGRFHVFDIGGNKLRLIALVRYGVQRLYIR
HVLDHASYDKGLWKEEIE

Download         Length: 297 bp

>T150321 NZ_CP064674:c1036486-1035959 [Salmonella sp. SJTUF14076]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTAGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14852.94 Da        Isoelectric Point: 4.4569

>AT150321 WP_068578624.1 NZ_CP049045:779115-779516 [Pseudomonas sp. BIOMIG1BAC]
MSVLVSQAAEHWQFVAPLLRKPRTEADYDALALALDELLDIMGEDEAHPLASLVDIIGDWIEAYDEEHRPIPPVSGVEVL
RSLMHEHGLTQSDLPGVGAQSVVSEVLSGKRQLNLRQVRWLSERFKVAMEVFA

Download         Length: 402 bp

>AT150321 NZ_CP064674:c1036773-1036483 [Salmonella sp. SJTUF14076]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6ZSS4

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6ZSS2

References