Detailed information of TA system TA150217

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4482842..4483100
• Replicon: chromosome
• Accession: NZ_CP048920
• Organism: Escherichia coli strain SCU-101

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: G4235_RS21780
• Protein ID: WP_000809168.1
• Coordinates: 4482948..4483100 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4482842..4482899 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G4235_RS21765	4478671..4479930	-	1260	WP_000494928.1	hypothetical protein	-
G4235_RS21770	4480059..4481552	-	1494	WP_001443162.1	sulfatase-like hydrolase/transferase	-
G4235_RS21775	4481572..4482333	-	762	WP_001274832.1	hypothetical protein	-
-	4482842..4482899	-	58	-	-	Antitoxin
G4235_RS21780	4482948..4483100	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
G4235_RS21785	4483205..4484335	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
G4235_RS21790	4484424..4486340	-	1917	WP_000516135.1	molecular chaperone DnaK	-
G4235_RS21795	4486712..4487116	+	405	WP_000843687.1	DUF2541 family protein	-
G4235_RS21800	4487142..4487855	+	714	WP_001102391.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T150217 WP_000809168.1 NZ_CP048920:4482948-4483100 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T150217 NZ_CP064405:2186168-2186545 [Mycobacterium tuberculosis variant bovis BCG]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT150217 NZ_CP048920:c4482899-4482842 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin