Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3261128..3261929 Replicon chromosome
Accession NZ_CP048920
Organism Escherichia coli strain SCU-101

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag G4235_RS16005 Protein ID WP_000854739.1
Coordinates 3261128..3261508 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag G4235_RS16010 Protein ID WP_001285482.1
Coordinates 3261555..3261929 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4235_RS15970 3256719..3257273 - 555 WP_001001909.1 molecular chaperone YcdY -
G4235_RS15975 3257297..3258034 - 738 WP_000283664.1 zinc-binding phosphatase -
G4235_RS15980 3258089..3259027 - 939 WP_000351287.1 glyoxylate/hydroxypyruvate reductase GhrA -
G4235_RS15990 3259514..3260341 - 828 WP_001304477.1 DUF4942 domain-containing protein -
G4235_RS15995 3260426..3260623 - 198 WP_000772027.1 DUF957 domain-containing protein -
G4235_RS16000 3260643..3261131 - 489 WP_001054232.1 hypothetical protein -
G4235_RS16005 3261128..3261508 - 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
G4235_RS16010 3261555..3261929 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
G4235_RS16015 3261979..3262623 - 645 WP_000086763.1 hypothetical protein -
G4235_RS16020 3262642..3262863 - 222 WP_000692315.1 DUF987 domain-containing protein -
G4235_RS16025 3262926..3263402 - 477 WP_001186170.1 RadC family protein -
G4235_RS16030 3263418..3263891 - 474 WP_001313575.1 antirestriction protein -
G4235_RS16035 3264154..3264975 - 822 WP_001234710.1 DUF945 domain-containing protein -
G4235_RS25940 3265056..3265267 + 212 Protein_3157 hypothetical protein -
G4235_RS16045 3265386..3265841 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T150213 WP_000854739.1 NZ_CP048920:c3261508-3261128 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T150213 NZ_CP064405:1752674-1753078 [Mycobacterium tuberculosis variant bovis BCG]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT150213 WP_001285482.1 NZ_CP048920:c3261929-3261555 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT150213 NZ_CP064405:1752465-1752668 [Mycobacterium tuberculosis variant bovis BCG]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References