Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2155115..2155946 Replicon chromosome
Accession NZ_CP048920
Organism Escherichia coli strain SCU-101

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag G4235_RS10415 Protein ID WP_000854814.1
Coordinates 2155115..2155489 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag G4235_RS10420 Protein ID WP_001560600.1
Coordinates 2155578..2155946 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G4235_RS10375 2150511..2151677 + 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
G4235_RS10380 2151796..2152269 + 474 WP_001560602.1 DNA gyrase inhibitor SbmC -
G4235_RS10385 2152467..2153525 + 1059 WP_001560601.1 FUSC family protein -
G4235_RS10390 2153697..2154026 + 330 WP_000450409.1 DUF496 family protein -
G4235_RS10395 2154127..2154309 - 183 WP_001016348.1 hypothetical protein -
G4235_RS10400 2154336..2154509 + 174 WP_032082634.1 transposase domain-containing protein -
G4235_RS10405 2154798..2154911 - 114 WP_001161660.1 DUF957 domain-containing protein -
G4235_RS10410 2154924..2155118 - 195 WP_000988600.1 hypothetical protein -
G4235_RS10415 2155115..2155489 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
G4235_RS10420 2155578..2155946 - 369 WP_001560600.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
G4235_RS10425 2156020..2156241 - 222 WP_000692315.1 DUF987 domain-containing protein -
G4235_RS10430 2156304..2156780 - 477 WP_001186170.1 RadC family protein -
G4235_RS10435 2156796..2157269 - 474 WP_001313575.1 antirestriction protein -
G4235_RS10440 2157532..2158353 - 822 WP_021561125.1 DUF945 domain-containing protein -
G4235_RS10445 2158574..2158984 - 411 WP_000846704.1 hypothetical protein -
G4235_RS10450 2159000..2159482 - 483 WP_001560596.1 hypothetical protein -
G4235_RS10455 2159814..2160884 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T150203 WP_000854814.1 NZ_CP048920:c2155489-2155115 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T150203 NZ_CP064405:843291-843719 [Mycobacterium tuberculosis variant bovis BCG]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTGGTGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13503.31 Da        Isoelectric Point: 5.9526

>AT150203 WP_001560600.1 NZ_CP048920:c2155946-2155578 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLANRAGIRGLSSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLACEADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT150203 NZ_CP064405:843010-843267 [Mycobacterium tuberculosis variant bovis BCG]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829FY50


Antitoxin

Source ID Structure

References