Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 247495..248091 Replicon chromosome
Accession NZ_CP048650
Organism Enterobacter roggenkampii strain Ecl_20_981

Toxin (Protein)


Gene name PumA Uniprot ID A0A0F1DED9
Locus tag G3T53_RS01105 Protein ID WP_023293553.1
Coordinates 247789..248091 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A837LKY9
Locus tag G3T53_RS01100 Protein ID WP_044598004.1
Coordinates 247495..247782 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3T53_RS01095 245867..247498 + 1632 WP_008503411.1 Na/Pi cotransporter family protein -
G3T53_RS01100 247495..247782 - 288 WP_044598004.1 putative addiction module antidote protein Antitoxin
G3T53_RS01105 247789..248091 - 303 WP_023293553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G3T53_RS01110 248289..249161 + 873 WP_039024655.1 23S rRNA pseudouridine(2604) synthase RluF -
G3T53_RS01115 249162..249434 - 273 WP_014830263.1 DUF3811 domain-containing protein -
G3T53_RS01120 249485..250429 - 945 WP_044597329.1 ketopantoate/pantoate/pantothenate transporter PanS -
G3T53_RS01125 250535..252109 - 1575 WP_044597328.1 RNA repair transcriptional activator RtcR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(4-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11459.24 Da        Isoelectric Point: 10.1771

>T149841 WP_023293553.1 NZ_CP048650:c248091-247789 [Enterobacter roggenkampii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDVKPVGEGISELRIHFGPGYRIYFKDQGNYIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T149841 NZ_CP064262:c1494-1228 [Klebsiella pneumoniae]
TTGGTCTGGACGATTAACTATTCCGATCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGAGTTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCGTTCTGTGTGAGATCCGAGATGACGAGCTTGTTATCCTTGCCGCCACGATT
GGACATCGCCGCGAAGTTTACGACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10142.50 Da        Isoelectric Point: 5.6306

>AT149841 WP_044598004.1 NZ_CP048650:c247782-247495 [Enterobacter roggenkampii]
MHNLTPYDPANALVDDEEIAVFIADALETGDSTYIAKALGVVARAKGMSNISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGFGLTLKHAGD

Download         Length: 288 bp

>AT149841 NZ_CP064262:c1702-1478 [Klebsiella pneumoniae]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
TTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAGGATTATTATCTTTCAGCAGAAACTGCTGCACGCGTTC
GCCGTGGTGATGAAGCAGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F1DED9

Antitoxin

Source ID Structure
AlphaFold DB A0A837LKY9

References