Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2961940..2962741 Replicon chromosome
Accession NZ_CP048647
Organism Escherichia coli strain GW-AmxH19

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag G3273_RS14275 Protein ID WP_000854739.1
Coordinates 2961940..2962320 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag G3273_RS14280 Protein ID WP_001285482.1
Coordinates 2962367..2962741 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G3273_RS14240 2957532..2958086 - 555 WP_001001921.1 molecular chaperone YcdY -
G3273_RS14245 2958110..2958847 - 738 WP_000283664.1 zinc-binding phosphatase -
G3273_RS14250 2958902..2959840 - 939 WP_000351277.1 glyoxylate/hydroxypyruvate reductase GhrA -
G3273_RS14260 2960326..2961153 - 828 WP_001518536.1 DUF4942 domain-containing protein -
G3273_RS14265 2961238..2961435 - 198 WP_000772027.1 DUF957 domain-containing protein -
G3273_RS14270 2961455..2961943 - 489 WP_001518535.1 hypothetical protein -
G3273_RS14275 2961940..2962320 - 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
G3273_RS14280 2962367..2962741 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
G3273_RS14285 2962791..2963435 - 645 WP_000086759.1 hypothetical protein -
G3273_RS14290 2963454..2963675 - 222 WP_000692315.1 DUF987 domain-containing protein -
G3273_RS14295 2963738..2964214 - 477 WP_001313574.1 RadC family protein -
G3273_RS14300 2964230..2964703 - 474 WP_001313575.1 antirestriction protein -
G3273_RS14305 2964797..2965042 - 246 WP_001164966.1 hypothetical protein -
G3273_RS14310 2965042..2965860 - 819 WP_001560884.1 DUF945 domain-containing protein -
G3273_RS14315 2966015..2966149 - 135 WP_032144430.1 DUF905 family protein -
G3273_RS14320 2966250..2966705 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T149829 WP_000854739.1 NZ_CP048647:c2962320-2961940 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T149829 NZ_CP064258:c4803184-4802651 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT149829 WP_001285482.1 NZ_CP048647:c2962741-2962367 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT149829 NZ_CP064258:c4803461-4803195 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References