Detailed information of TA system TA149812

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 197928..198150
• Replicon: chromosome
• Accession: NZ_CP048647
• Organism: Escherichia coli strain GW-AmxH19

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A0D6GD35
• Locus tag: G3273_RS00945
• Protein ID: WP_000170745.1
• Coordinates: 198043..198150 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	197928..197986 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G3273_RS00925	193369..194271	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
G3273_RS00930	194282..195265	+	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
G3273_RS00935	195262..196266	+	1005	WP_000103583.1	dipeptide ABC transporter ATP-binding subunit DppF	-
G3273_RS00940	196296..197567	-	1272	WP_001467807.1	amino acid permease	-
-	197928..197986	-	59	-	-	Antitoxin
G3273_RS00945	198043..198150	+	108	WP_000170745.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
G3273_RS00950	198237..199916	-	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
G3273_RS00955	199913..200104	-	192	WP_000988311.1	cellulose biosynthesis protein BcsF	-
G3273_RS00960	200101..201672	-	1572	WP_001204945.1	cellulose biosynthesis protein BcsE	-
G3273_RS00965	201945..202133	+	189	WP_001063314.1	YhjR family protein	-
G3273_RS00970	202145..202897	+	753	WP_000279525.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3855.68 Da
• Isoelectric Point: 9.0157

>T149812 WP_000170745.1 NZ_CP048647:198043-198150 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVSWLNKRK

Nucleotide

• Length: 108 bp

>T149812 NZ_CP064252:c4822726-4822193 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT149812 NZ_CP048647:c197986-197928 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A0D6GD35

Antitoxin