Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2464242..2464880 Replicon chromosome
Accession NZ_CP048371
Organism Escherichia coli strain 163

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag GZS08_RS11740 Protein ID WP_001447010.1
Coordinates 2464704..2464880 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GZS08_RS11735 Protein ID WP_001270286.1
Coordinates 2464242..2464658 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZS08_RS11715 2459394..2460335 - 942 WP_001251304.1 ABC transporter permease -
GZS08_RS11720 2460336..2461349 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
GZS08_RS11725 2461367..2462512 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
GZS08_RS11730 2462757..2464163 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
GZS08_RS11735 2464242..2464658 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
GZS08_RS11740 2464704..2464880 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
GZS08_RS11745 2465102..2465332 + 231 WP_000494244.1 YncJ family protein -
GZS08_RS11750 2465424..2467385 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
GZS08_RS11755 2467458..2467994 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
GZS08_RS11760 2468047..2469261 + 1215 WP_071790389.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T149265 WP_001447010.1 NZ_CP048371:c2464880-2464704 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T149265 NZ_CP063983:197059-197166 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT149265 WP_001270286.1 NZ_CP048371:c2464658-2464242 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT149265 NZ_CP063983:c197010-196947 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References