Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1943829..1944664 Replicon chromosome
Accession NZ_CP048367
Organism Escherichia coli strain 164

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1U9SHU4
Locus tag GZS07_RS09270 Protein ID WP_000854752.1
Coordinates 1943829..1944206 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag GZS07_RS09275 Protein ID WP_001278232.1
Coordinates 1944296..1944664 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZS07_RS09230 1939349..1939822 + 474 WP_001105384.1 DNA gyrase inhibitor SbmC -
GZS07_RS09235 1940020..1941078 + 1059 WP_001200892.1 FUSC family protein -
GZS07_RS09240 1941250..1941579 + 330 WP_000450409.1 DUF496 family protein -
GZS07_RS09245 1941680..1941862 - 183 WP_024167529.1 ethanolamine utilization protein -
GZS07_RS09255 1942316..1943344 - 1029 Protein_1806 IS110 family transposase -
GZS07_RS09260 1943503..1943616 - 114 WP_001161660.1 DUF957 domain-containing protein -
GZS07_RS09265 1943629..1943832 - 204 WP_000761705.1 hypothetical protein -
GZS07_RS09270 1943829..1944206 - 378 WP_000854752.1 TA system toxin CbtA family protein Toxin
GZS07_RS09275 1944296..1944664 - 369 WP_001278232.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
GZS07_RS09280 1944827..1945048 - 222 WP_000692345.1 DUF987 domain-containing protein -
GZS07_RS09285 1945111..1945587 - 477 WP_001186774.1 RadC family protein -
GZS07_RS09290 1945801..1947342 + 1542 WP_002431311.1 IS21-like element ISEc12 family transposase -
GZS07_RS09295 1947357..1948103 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
GZS07_RS09300 1948189..1948662 - 474 WP_000855059.1 antirestriction protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14076.08 Da        Isoelectric Point: 8.2905

>T149223 WP_000854752.1 NZ_CP048367:c1944206-1943829 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T149223 NZ_CP063953:207686-207904 [Klebsiella variicola]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCCGCCGATCATCGTCTGGCTGAAC
TGACCATGAATAAGCTGTACGATAAGATCCCGACCTCAGTCTGGAAGTTTATCCGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT149223 WP_001278232.1 NZ_CP048367:c1944664-1944296 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT149223 NZ_CP063953:207285-207659 [Klebsiella variicola]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACTTCGGCTGTCAATCTTCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCGCTTAATTATAAAATTAAGTACACTGAGGATAATAAACTGGTCGCTCAGGTTGACGAATATCTG
GACGATACTTTTACCTTGTTCAGTAACTACGGCATTAACTCAACGGATTTGCAAAAGTGGAAAAAATCCGGTAATCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTCTCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9SHU4

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References