Detailed information of TA system TA149193

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4092427..4092685
• Replicon: chromosome
• Accession: NZ_CP048359
• Organism: Escherichia coli strain 53

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: GZS09_RS19590
• Protein ID: WP_000809168.1
• Coordinates: 4092533..4092685 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4092427..4092484 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GZS09_RS19570	4087453..4088805	+	1353	Protein_3834	fimbria/pilus outer membrane usher protein	-
GZS09_RS19575	4088818..4089777	+	960	WP_000871656.1	hypothetical protein	-
GZS09_RS19580	4089816..4090715	-	900	WP_001300855.1	transcriptional activator NhaR	-
GZS09_RS19585	4090781..4091947	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	4092427..4092484	-	58	-	-	Antitoxin
GZS09_RS19590	4092533..4092685	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
GZS09_RS19595	4092879..4093991	-	1113	WP_001300563.1	IS4-like element IS421 family transposase	-
GZS09_RS19600	4094138..4095268	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
GZS09_RS19605	4095357..4097273	-	1917	WP_000516135.1	molecular chaperone DnaK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T149193 WP_000809168.1 NZ_CP048359:4092533-4092685 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T149193 NZ_CP063943:1298981-1299313 [Klebsiella pneumoniae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGACTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGGACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGTCGTTGTCAACGAGGTGCTTGCCAGGCTGGATGC
GATGCTGAGTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT149193 NZ_CP048359:c4092484-4092427 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin