Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1253965..1254799 Replicon chromosome
Accession NZ_CP048304
Organism Escherichia coli strain 9

Toxin (Protein)


Gene name yeeV Uniprot ID S1PLF5
Locus tag GZS17_RS05950 Protein ID WP_000854690.1
Coordinates 1253965..1254342 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1P7N8
Locus tag GZS17_RS05955 Protein ID WP_001305076.1
Coordinates 1254431..1254799 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GZS17_RS05920 1250359..1250514 - 156 WP_000729638.1 hypothetical protein -
GZS17_RS05925 1250946..1251879 - 934 Protein_1142 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
GZS17_RS05930 1251872..1252267 - 396 WP_000208382.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
GZS17_RS05935 1252336..1253181 - 846 WP_001529401.1 DUF4942 domain-containing protein -
GZS17_RS05940 1253266..1253463 - 198 WP_000839293.1 DUF957 domain-containing protein -
GZS17_RS05945 1253480..1253968 - 489 WP_000761699.1 hypothetical protein -
GZS17_RS05950 1253965..1254342 - 378 WP_000854690.1 TA system toxin CbtA family protein Toxin
GZS17_RS05955 1254431..1254799 - 369 WP_001305076.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GZS17_RS05960 1254849..1255493 - 645 WP_000094916.1 hypothetical protein -
GZS17_RS05965 1255512..1255733 - 222 WP_000692329.1 DUF987 domain-containing protein -
GZS17_RS05970 1255796..1256272 - 477 WP_001186726.1 RadC family protein -
GZS17_RS05975 1256288..1256773 - 486 WP_000849565.1 antirestriction protein -
GZS17_RS05980 1256828..1257649 - 822 WP_162655221.1 DUF945 domain-containing protein -
GZS17_RS05985 1257750..1257983 - 234 WP_000902034.1 DUF905 family protein -
GZS17_RS05990 1258062..1258517 - 456 WP_000581502.1 hypothetical protein -
GZS17_RS05995 1258593..1259720 - 1128 Protein_1156 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1251139..1296549 45410


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14057.04 Da        Isoelectric Point: 9.1510

>T148962 WP_000854690.1 NZ_CP048304:c1254342-1253965 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T148962 NZ_CP063910:c3023466-3023119 [Klebsiella variicola]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGGTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13560.39 Da        Isoelectric Point: 4.7830

>AT148962 WP_001305076.1 NZ_CP048304:c1254799-1254431 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT148962 NZ_CP063910:c3023119-3022820 [Klebsiella variicola]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGATCCGCGGCTTTCGACCCTAAAACGCTACATTGCGGCACTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1PLF5


Antitoxin

Source ID Structure
AlphaFold DB S1P7N8

References