Detailed information of TA system TA148929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1582504..1583189
• Replicon: chromosome
• Accession: NZ_CP048254
• Organism: Neisseria gonorrhoeae strain CT530

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q5F6D1
• Locus tag: GYN04_RS08205
• Protein ID: WP_003689143.1
• Coordinates: 1583007..1583189 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q5F6D2
• Locus tag: GYN04_RS08200
• Protein ID: WP_003691454.1
• Coordinates: 1582504..1582905 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GYN04_RS08140 (GYN04_07925)	1577553..1577768	-	216	WP_003691538.1	hypothetical protein	-
GYN04_RS08145 (GYN04_07930)	1577820..1578311	-	492	WP_003691537.1	siphovirus Gp157 family protein	-
GYN04_RS08150 (GYN04_07935)	1578308..1578466	-	159	WP_250328365.1	hypothetical protein	-
GYN04_RS08155	1578625..1578849	-	225	WP_250328366.1	hypothetical protein	-
GYN04_RS08160	1578958..1579311	-	354	WP_250328367.1	hypothetical protein	-
GYN04_RS08165	1579325..1579540	-	216	WP_250328368.1	hypothetical protein	-
GYN04_RS08170 (GYN04_07945)	1579581..1579814	-	234	WP_250328369.1	hypothetical protein	-
GYN04_RS08175 (GYN04_07950)	1579967..1580299	-	333	WP_003696914.1	hypothetical protein	-
GYN04_RS08180 (GYN04_07955)	1580440..1580727	-	288	WP_196374913.1	hypothetical protein	-
GYN04_RS08185 (GYN04_07960)	1580724..1581200	-	477	WP_002255718.1	hypothetical protein	-
GYN04_RS08190 (GYN04_07965)	1581233..1581433	-	201	WP_047954343.1	hypothetical protein	-
GYN04_RS08195 (GYN04_07970)	1581644..1582405	+	762	WP_012503753.1	hypothetical protein	-
GYN04_RS08200 (GYN04_07975)	1582504..1582905	-	402	WP_003691454.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GYN04_RS08205 (GYN04_07980)	1583007..1583189	-	183	WP_003689143.1	type II toxin-antitoxin system HicA family toxin	Toxin
GYN04_RS08210 (GYN04_07985)	1583359..1584177	-	819	WP_012503752.1	DUF3037 domain-containing protein	-
GYN04_RS08215 (GYN04_07990)	1584174..1584872	-	699	WP_003689139.1	hypothetical protein	-
GYN04_RS08220 (GYN04_07995)	1585111..1585821	-	711	WP_050161643.1	helix-turn-helix transcriptional regulator	-
GYN04_RS08225 (GYN04_08000)	1585937..1586125	+	189	WP_003689136.1	helix-turn-helix domain-containing protein	-
GYN04_RS08230	1586205..1586360	+	156	WP_003691446.1	hypothetical protein	-
GYN04_RS08235 (GYN04_08005)	1586337..1586522	-	186	WP_250328370.1	hypothetical protein	-
GYN04_RS08240 (GYN04_08010)	1586694..1586921	+	228	WP_003691442.1	helix-turn-helix domain-containing protein	-
GYN04_RS08245 (GYN04_08015)	1586918..1587943	+	1026	WP_250328371.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1567324..1600830	33506

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6687.77 Da
• Isoelectric Point: 10.7235

>T148929 WP_003689143.1 NZ_CP048254:c1583189-1583007 [Neisseria gonorrhoeae]
MNSLDVIALLKQDGWYKVAQSGSHSQYKHPTKKGRVTVPHPKKDLPTGTVKNIYKQAGLK

Nucleotide

• Length: 183 bp

>T148929 NZ_CP063905:48731-49213 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCACTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGAAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGTGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14634.43 Da
• Isoelectric Point: 4.5457

>AT148929 WP_003691454.1 NZ_CP048254:c1582905-1582504 [Neisseria gonorrhoeae]
MFIPAALHKDEHSAYGVTIPDLPGCFSCGDTVEEAVANARSAAYMHIDGMIEDGGFKNLAVSSIADLSQEPDYHGATWVM
IEIDPAKISRQQIRFNVSWPQYLLDRVDEYTSANHETRSGFLAKAALLTMNQA

Nucleotide

• Length: 402 bp

>AT148929 NZ_CP063905:48477-48743 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGTACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGATTCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: Q5F6D1

Antitoxin

• AlphaFold DB: Q5F6D2