Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ldrD-agrB/Ldr(toxin) |
| Location | 330706..330927 | Replicon | chromosome |
| Accession | NZ_CP048025 | ||
| Organism | Escherichia coli strain GZEC065 | ||
Toxin (Protein)
| Gene name | ldrD | Uniprot ID | S1PGT3 |
| Locus tag | GWG09_RS01655 | Protein ID | WP_000170954.1 |
| Coordinates | 330706..330813 (-) | Length | 36 a.a. |
Antitoxin (RNA)
| Gene name | agrB | ||
| Locus tag | - | ||
| Coordinates | 330861..330927 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GWG09_RS01630 | 326550..327632 | + | 1083 | WP_000804726.1 | peptide chain release factor 1 | - |
| GWG09_RS01635 | 327632..328465 | + | 834 | WP_000456469.1 | peptide chain release factor N(5)-glutamine methyltransferase | - |
| GWG09_RS01640 | 328462..328854 | + | 393 | WP_000200378.1 | invasion regulator SirB2 | - |
| GWG09_RS01645 | 328858..329667 | + | 810 | WP_001257044.1 | invasion regulator SirB1 | - |
| GWG09_RS01650 | 329703..330557 | + | 855 | WP_000811065.1 | 3-deoxy-8-phosphooctulonate synthase | - |
| GWG09_RS01655 | 330706..330813 | - | 108 | WP_000170954.1 | type I toxin-antitoxin system toxin Ldr family protein | Toxin |
| - | 330861..330927 | + | 67 | NuclAT_12 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_12 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_12 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_12 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_15 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_15 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_15 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_15 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_18 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_18 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_18 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_18 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_21 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_21 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_21 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_21 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_24 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_24 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_24 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_24 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_27 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_27 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_27 | - | Antitoxin |
| - | 330861..330927 | + | 67 | NuclAT_27 | - | Antitoxin |
| - | 330863..330926 | + | 64 | NuclAT_32 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_32 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_32 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_32 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_35 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_35 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_35 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_35 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_38 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_38 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_38 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_38 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_41 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_41 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_41 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_41 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_44 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_44 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_44 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_44 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_47 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_47 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_47 | - | - |
| - | 330863..330926 | + | 64 | NuclAT_47 | - | - |
| GWG09_RS01660 | 331241..331348 | - | 108 | WP_000170926.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| - | 331401..331462 | + | 62 | NuclAT_30 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_30 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_30 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_30 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_33 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_33 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_33 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_33 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_36 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_36 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_36 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_36 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_39 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_39 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_39 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_39 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_42 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_42 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_42 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_42 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_45 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_45 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_45 | - | - |
| - | 331401..331462 | + | 62 | NuclAT_45 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_13 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_13 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_13 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_13 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_16 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_16 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_16 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_16 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_19 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_19 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_19 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_19 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_22 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_22 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_22 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_22 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_25 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_25 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_25 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_25 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_28 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_28 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_28 | - | - |
| - | 331401..331463 | + | 63 | NuclAT_28 | - | - |
| - | 331401..331464 | + | 64 | NuclAT_48 | - | - |
| - | 331401..331464 | + | 64 | NuclAT_48 | - | - |
| - | 331401..331464 | + | 64 | NuclAT_48 | - | - |
| - | 331401..331464 | + | 64 | NuclAT_48 | - | - |
| - | 331401..331464 | + | 64 | NuclAT_50 | - | - |
| - | 331401..331464 | + | 64 | NuclAT_50 | - | - |
| - | 331401..331464 | + | 64 | NuclAT_50 | - | - |
| - | 331401..331464 | + | 64 | NuclAT_50 | - | - |
| - | 331401..331464 | + | 64 | NuclAT_52 | - | - |
| - | 331401..331464 | + | 64 | NuclAT_52 | - | - |
| - | 331401..331464 | + | 64 | NuclAT_52 | - | - |
| - | 331401..331464 | + | 64 | NuclAT_52 | - | - |
| GWG09_RS24560 | 331777..331884 | - | 108 | WP_000170926.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| - | 331937..331998 | + | 62 | NuclAT_31 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_31 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_31 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_31 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_34 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_34 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_34 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_34 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_37 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_37 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_37 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_37 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_40 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_40 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_40 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_40 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_43 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_43 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_43 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_43 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_46 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_46 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_46 | - | - |
| - | 331937..331998 | + | 62 | NuclAT_46 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_14 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_14 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_14 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_14 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_17 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_17 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_17 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_17 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_20 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_20 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_20 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_20 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_23 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_23 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_23 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_23 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_26 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_26 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_26 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_26 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_29 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_29 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_29 | - | - |
| - | 331937..331999 | + | 63 | NuclAT_29 | - | - |
| - | 331937..332000 | + | 64 | NuclAT_49 | - | - |
| - | 331937..332000 | + | 64 | NuclAT_49 | - | - |
| - | 331937..332000 | + | 64 | NuclAT_49 | - | - |
| - | 331937..332000 | + | 64 | NuclAT_49 | - | - |
| - | 331937..332000 | + | 64 | NuclAT_51 | - | - |
| - | 331937..332000 | + | 64 | NuclAT_51 | - | - |
| - | 331937..332000 | + | 64 | NuclAT_51 | - | - |
| - | 331937..332000 | + | 64 | NuclAT_51 | - | - |
| - | 331937..332000 | + | 64 | NuclAT_53 | - | - |
| - | 331937..332000 | + | 64 | NuclAT_53 | - | - |
| - | 331937..332000 | + | 64 | NuclAT_53 | - | - |
| - | 331937..332000 | + | 64 | NuclAT_53 | - | - |
| GWG09_RS01670 | 332290..333390 | - | 1101 | WP_001295620.1 | sodium-potassium/proton antiporter ChaA | - |
| GWG09_RS01675 | 333660..333890 | + | 231 | WP_001146442.1 | putative cation transport regulator ChaB | - |
| GWG09_RS01680 | 334048..334743 | + | 696 | WP_001355927.1 | glutathione-specific gamma-glutamylcyclotransferase | - |
| GWG09_RS01685 | 334787..335140 | - | 354 | WP_001169669.1 | DsrE/F sulfur relay family protein YchN | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 36 a.a. Molecular weight: 3983.80 Da Isoelectric Point: 11.4779
>T148702 WP_000170954.1 NZ_CP048025:c330813-330706 [Escherichia coli]
MTLAQFAMIFWHDLAAPILAGIITAAIVGWWRNRK
MTLAQFAMIFWHDLAAPILAGIITAAIVGWWRNRK
Download Length: 108 bp
>T148702 NZ_CP063851:c2560652-2560269 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCATCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 67 bp
>AT148702 NZ_CP048025:330861-330927 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
