Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1-Phd |
| Location | 3182331..3183016 | Replicon | chromosome |
| Accession | NZ_CP047972 | ||
| Organism | Kyrpidia spormannii strain COOX1 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | D5WX22 |
| Locus tag | GWK42_RS15535 | Protein ID | WP_013077082.1 |
| Coordinates | 3182579..3183016 (+) | Length | 146 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | GWK42_RS15530 | Protein ID | WP_170086639.1 |
| Coordinates | 3182331..3182582 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GWK42_RS15490 | 3177631..3177933 | + | 303 | WP_170086635.1 | hypothetical protein | - |
| GWK42_RS15495 | 3178302..3178727 | - | 426 | WP_170086636.1 | putative toxin-antitoxin system toxin component, PIN family | - |
| GWK42_RS15500 | 3178724..3179014 | - | 291 | WP_170086637.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GWK42_RS16685 | 3179013..3179174 | + | 162 | WP_232059769.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| GWK42_RS16690 | 3179286..3179531 | + | 246 | WP_232059770.1 | PIN domain-containing protein | - |
| GWK42_RS15515 | 3179517..3180098 | - | 582 | WP_232059771.1 | ImmA/IrrE family metallo-endopeptidase | - |
| GWK42_RS16695 | 3180228..3180803 | - | 576 | WP_232059772.1 | zinc ribbon domain-containing protein | - |
| GWK42_RS16700 | 3180758..3181537 | - | 780 | WP_232059773.1 | hypothetical protein | - |
| GWK42_RS15525 | 3181720..3182097 | - | 378 | WP_170086638.1 | hypothetical protein | - |
| GWK42_RS15530 | 3182331..3182582 | + | 252 | WP_170086639.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GWK42_RS15535 | 3182579..3183016 | + | 438 | WP_013077082.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| GWK42_RS16705 | 3183215..3183304 | + | 90 | WP_232059774.1 | putative holin-like toxin | - |
| GWK42_RS15540 | 3184012..3184536 | - | 525 | WP_170086640.1 | Uma2 family endonuclease | - |
| GWK42_RS15545 | 3184567..3184800 | - | 234 | WP_170086641.1 | hypothetical protein | - |
| GWK42_RS15550 | 3184848..3185183 | - | 336 | WP_170086642.1 | PIN domain-containing protein | - |
| GWK42_RS15555 | 3185176..3185700 | - | 525 | WP_232059865.1 | IS630 family transposase | - |
| GWK42_RS15560 | 3185690..3186235 | - | 546 | WP_170085301.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 146 a.a. Molecular weight: 16377.81 Da Isoelectric Point: 7.1375
>T148620 WP_013077082.1 NZ_CP047972:3182579-3183016 [Kyrpidia spormannii]
VKYLLDTCVISELVKKAPAPAVLRWVENQDEENLYLSVLTLGELQRGVSKLLDRSRAEQLQAWLNDDLTHRFQRRILPVD
QKVAKAWGEISGDAARRGETLPVMDSLIAATAQVHGLVVVTRNVRDIERCRVPVTNPWPDTRADL
VKYLLDTCVISELVKKAPAPAVLRWVENQDEENLYLSVLTLGELQRGVSKLLDRSRAEQLQAWLNDDLTHRFQRRILPVD
QKVAKAWGEISGDAARRGETLPVMDSLIAATAQVHGLVVVTRNVRDIERCRVPVTNPWPDTRADL
Download Length: 438 bp
>T148620 NZ_CP063804:2232672-2233070 [Mycobacterium orygis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9465.93 Da Isoelectric Point: 9.9218
>AT148620 WP_170086639.1 NZ_CP047972:3182331-3182582 [Kyrpidia spormannii]
MDKTWQLQDAKNRLSELVNKAMRNGPQMITVRGKPAVVVVSVQEYERLAHPKASLVEFFRNSPLVGVELDVERLRDHPRE
AGL
MDKTWQLQDAKNRLSELVNKAMRNGPQMITVRGKPAVVVVSVQEYERLAHPKASLVEFFRNSPLVGVELDVERLRDHPRE
AGL
Download Length: 252 bp
>AT148620 NZ_CP063804:2232444-2232671 [Mycobacterium orygis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCGACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCGACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|