Detailed information of TA system TA148619

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 375472..376091
• Replicon: chromosome
• Accession: NZ_CP047972
• Organism: Kyrpidia spormannii strain COOX1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GWK42_RS01965
• Protein ID: WP_170084800.1
• Coordinates: 375705..376091 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: D5WW04
• Locus tag: GWK42_RS01960
• Protein ID: WP_013074928.1
• Coordinates: 375472..375708 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWK42_RS01950	372381..373583	+	1203	WP_269152992.1	transposase	-
GWK42_RS01955	373984..375225	+	1242	WP_170084799.1	transposase	-
GWK42_RS01960	375472..375708	+	237	WP_013074928.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GWK42_RS01965	375705..376091	+	387	WP_170084800.1	type II toxin-antitoxin system VapC family toxin	Toxin
GWK42_RS01970	376486..377496	-	1011	WP_170084801.1	GTP-binding protein	-
GWK42_RS01975	377510..377848	-	339	WP_170084802.1	hypothetical protein	-
GWK42_RS01980	377928..378812	-	885	WP_170084803.1	polysaccharide deacetylase	-
GWK42_RS01985	378837..379802	-	966	WP_170084804.1	asparaginase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-44)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14884.15 Da
• Isoelectric Point: 4.7434

>T148619 WP_170084800.1 NZ_CP047972:375705-376091 [Kyrpidia spormannii]
MKTLLDTHVFLWWITDDGRMSKRARAIIQDTRNELYLSAASAWEIAIKAALGRIRVYEDLDRFMTQQMNENGIVDLPVEI
LHALGVYGLPDLHRDPFDRLLVAQAIQEGMPIITADEWIKRYDVETIW

Nucleotide

• Length: 387 bp

>T148619 NZ_CP063804:c2209048-2208704 [Mycobacterium orygis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8746.21 Da
• Isoelectric Point: 10.2014

>AT148619 WP_013074928.1 NZ_CP047972:375472-375708 [Kyrpidia spormannii]
VTKVVNVHEAKTHFSKLLARVEVGEEIVIAKAGKPLARLVPYRERPTKRVPGTAKSLIVVGEDFDDPLPESIQRLFER

Nucleotide

• Length: 237 bp

>AT148619 NZ_CP063804:c2209290-2209042 [Mycobacterium orygis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A6F9E101