Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1996650..1998214 Replicon chromosome
Accession NZ_CP047962
Organism Aeromonas media strain MC64

Toxin (Protein)


Gene name hipA Uniprot ID A0A3G9I6T8
Locus tag GWI30_RS09410 Protein ID WP_064338156.1
Coordinates 1996650..1997960 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GWI30_RS09415 Protein ID WP_005329233.1
Coordinates 1997960..1998214 (-) Length 85 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GWI30_RS09385 1992267..1992722 + 456 WP_161507131.1 YbjN domain-containing protein -
GWI30_RS09400 1993364..1995537 - 2174 Protein_1807 catalase/peroxidase HPI -
GWI30_RS09410 1996650..1997960 - 1311 WP_064338156.1 type II toxin-antitoxin system HipA family toxin Toxin
GWI30_RS09415 1997960..1998214 - 255 WP_005329233.1 helix-turn-helix domain-containing protein Antitoxin
GWI30_RS09420 1998716..1998964 + 249 WP_161507132.1 hypothetical protein -
GWI30_RS09425 1999385..1999636 - 252 WP_010674977.1 plasmid stabilization protein -
GWI30_RS09430 1999715..2001097 - 1383 WP_201035452.1 Fic family protein -
GWI30_RS09435 2001277..2001729 + 453 WP_021140686.1 DUF2384 domain-containing protein -
GWI30_RS09440 2002061..2002639 + 579 WP_021140685.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-104)

Antitoxin

(13-65)


Sequences


Toxin        


Download         Length: 437 a.a.        Molecular weight: 49124.32 Da        Isoelectric Point: 7.1717

>T148586 WP_064338156.1 NZ_CP047962:c1997960-1996650 [Aeromonas media]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKRIECKPLSDAELEQIMTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKAIGFEQVQMEKIISELTDNL
DEVISIVRQQLPDTFPTEIADSILGGLSSRAQRLKR

Download         Length: 1311 bp

>T148586 NZ_CP063804:71587-71988 [Mycobacterium orygis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9271.66 Da        Isoelectric Point: 9.1571

>AT148586 WP_005329233.1 NZ_CP047962:c1998214-1997960 [Aeromonas media]
MKVTSAKQLSACLKDARLSQKLSQGKVAGKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENATPGW
KEEW

Download         Length: 255 bp

>AT148586 NZ_CP063804:71355-71594 [Mycobacterium orygis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3G9I6T8


Antitoxin

Source ID Structure

References