Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 890538..891139 Replicon chromosome
Accession NZ_CP047939
Organism Synechococcus sp. BMK-MC-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag SynBMKMC1_RS04930 Protein ID WP_186472912.1
Coordinates 890780..891139 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag SynBMKMC1_RS04925 Protein ID WP_186472911.1
Coordinates 890538..890780 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SynBMKMC1_RS04875 886020..886223 + 204 WP_186472906.1 DUF1211 domain-containing protein -
SynBMKMC1_RS04880 886144..886341 - 198 WP_186473508.1 hypothetical protein -
SynBMKMC1_RS04885 886493..886765 - 273 WP_186473329.1 hypothetical protein -
SynBMKMC1_RS04890 886957..887220 + 264 WP_186472907.1 hypothetical protein -
SynBMKMC1_RS04895 887494..887724 + 231 WP_186472908.1 hypothetical protein -
SynBMKMC1_RS04900 887901..888635 - 735 WP_186473330.1 aquaporin Z -
SynBMKMC1_RS04905 889120..889329 - 210 Protein_957 acid phosphatase -
SynBMKMC1_RS04910 889318..889509 + 192 Protein_958 tyrosine-type recombinase/integrase -
SynBMKMC1_RS04915 889725..890027 + 303 WP_186472909.1 type II toxin-antitoxin system RelE/ParE family toxin -
SynBMKMC1_RS04920 890027..890335 + 309 WP_186472910.1 putative addiction module antidote protein -
SynBMKMC1_RS04925 890538..890780 + 243 WP_186472911.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SynBMKMC1_RS04930 890780..891139 + 360 WP_186472912.1 endoribonuclease MazF Toxin
SynBMKMC1_RS04935 891539..891874 + 336 WP_186472913.1 type II toxin-antitoxin system PemK/MazF family toxin -
SynBMKMC1_RS04940 892402..892857 + 456 WP_186472914.1 GNAT family N-acetyltransferase -
SynBMKMC1_RS04945 893018..893779 + 762 WP_186472915.1 hypothetical protein -
SynBMKMC1_RS04950 893893..894330 + 438 WP_186472916.1 GNAT family N-acetyltransferase -
SynBMKMC1_RS04955 894501..895019 + 519 WP_186472917.1 N-acetyltransferase -
SynBMKMC1_RS04960 895277..895417 + 141 WP_186472918.1 hypothetical protein -
SynBMKMC1_RS04965 895437..895637 - 201 WP_041428798.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-111)

Antitoxin

SpoVT-AbrB domain

(6-47)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 12811.88 Da        Isoelectric Point: 8.9893

>T148555 WP_186472912.1 NZ_CP047939:890780-891139 [Synechococcus sp. BMK-MC-1]
VTAAYVPDRGDLVWLEFTPQTGSEQAGRRPALVISPRAYNARVGLALFCPVTSRVKGYPFEVALPEGSGVVGVVLADQLK
SLDWRARKAKLIEHASSEVLAMVTVRILPLLDPGNSVTL

Download         Length: 360 bp

>T148555 NZ_CP063774:2886615-2886926 [Escherichia coli O25b:H4-ST131]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8400.54 Da        Isoelectric Point: 4.7023

>AT148555 WP_186472911.1 NZ_CP047939:890538-890780 [Synechococcus sp. BMK-MC-1]
VQTRVQKWGNSLGVRIPRGLAEEVGLGAGTEVSLSTKDGELVVKPFVPARLSLDDLLAEVSEKNLHSAIDTGSAVGAEIF

Download         Length: 243 bp

>AT148555 NZ_CP063774:2886927-2887217 [Escherichia coli O25b:H4-ST131]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References