Detailed information of TA system TA148060

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2292402..2292586
• Replicon: chromosome
• Accession: NZ_CP047813
• Organism: Staphylococcus aureus strain UP_1500

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: E3T09_RS11175
• Protein ID: WP_000482647.1
• Coordinates: 2292402..2292509 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2292526..2292586 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T09_RS11150	2287764..2288237	+	474	WP_043044951.1	GyrI-like domain-containing protein	-
E3T09_RS11155	2288360..2289571	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
E3T09_RS11160	2289753..2290412	-	660	WP_043044952.1	membrane protein	-
E3T09_RS11165	2290472..2291614	-	1143	WP_001176863.1	glycerate kinase	-
E3T09_RS11170	2291882..2292268	+	387	WP_000779357.1	flippase GtxA	-
E3T09_RS11175	2292402..2292509	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2292526..2292586	-	61	-	-	Antitoxin
E3T09_RS11180	2293213..2294976	+	1764	WP_043044953.1	ABC transporter ATP-binding protein/permease	-
E3T09_RS11185	2295001..2296734	+	1734	WP_160186742.1	ABC transporter ATP-binding protein/permease	-
E3T09_RS11190	2296965..2297132	+	168	WP_001789205.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T148060 WP_000482647.1 NZ_CP047813:2292402-2292509 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T148060 NZ_CP063418:1180349-1180774 [Actinomyces sp. ZJ34]
GTGATTGTCCTCGACACGAATGTGCTTTCTGAGCCTCTGCGGCGCGATCCTGATCCTCGCGTCGCACGTTGGTTGGATGA
TCAGCATCCGAGGACCCTTTATGTCACGGCGCTGACCCTGGCGGAGCTGCGTGCCGGTGTGGAGATCCTGCCTTCAGGAC
GTCGACGCGATCTTCTCCGGGAACGGCTTGAGGAAGAGGTCATTCCGTTCTTCGAGGATCGAGTCCTGCCATTCGACGGC
CGAGCCTCACGTGCTTGGGCGCGGCTCCAGGCTCATGCTCGTACTCACGGTCGACCGTTGCCTGTGATGGACTCGCTTAT
CGCTGCTGTCGTGAGCGCGCGAGGTTATGCCTTGGCTACCCGCAATACTGCGGACTTCGCCGCGACAGGCGTAGAGCTGA
TCAACCCGTGGGAAGCGGTCGTCTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT148060 NZ_CP047813:c2292586-2292526 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin