Detailed information of TA system TA147989

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 511563..512142
• Replicon: chromosome
• Accession: NZ_CP047805
• Organism: Staphylococcus aureus strain UP_1654

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: E3T17_RS02725
• Protein ID: WP_001025401.1
• Coordinates: 511563..511808 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	511777..512142 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T17_RS02685	507677..508291	+	615	WP_000191466.1	hypothetical protein	-
E3T17_RS02690	508288..508434	-	147	WP_001795334.1	hypothetical protein	-
E3T17_RS02695	508471..508653	-	183	WP_000705240.1	hypothetical protein	-
E3T17_RS02700	508749..509669	-	921	WP_000348133.1	3'-5' exoribonuclease	-
E3T17_RS02705	509685..510299	-	615	WP_000801423.1	XRE family transcriptional regulator	-
E3T17_RS02710	510471..510698	+	228	WP_160325449.1	BetR domain protein	-
E3T17_RS02715	510724..511279	+	556	Protein_504	phage antirepressor KilAC domain-containing protein	-
E3T17_RS02720	511295..511513	+	219	WP_001001383.1	hypothetical protein	-
E3T17_RS02725	511563..511808	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
E3T17_RS02730	511777..512142	-	366	WP_001128433.1	hypothetical protein	Antitoxin
E3T17_RS02735	512197..512412	+	216	WP_001097552.1	hypothetical protein	-
E3T17_RS02740	512437..512700	+	264	WP_001124157.1	helix-turn-helix domain-containing protein	-
E3T17_RS02745	512713..512874	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
E3T17_RS02750	512953..513276	+	324	WP_000174998.1	hypothetical protein	-
E3T17_RS02755	513291..513653	+	363	WP_000985972.1	hypothetical protein	-
E3T17_RS02760	513650..514816	+	1167	WP_000762530.1	DUF2800 domain-containing protein	-
E3T17_RS02765	514842..515399	+	558	WP_000645048.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T147989 WP_001025401.1 NZ_CP047805:511563-511808 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T147989 NZ_CP063389:c4636246-4635491 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGTTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT147989 NZ_CP047805:c512142-511777 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin