Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1827244..1827758 Replicon chromosome
Accession NZ_CP047802
Organism Staphylococcus aureus strain UP_1442

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag E3S67_RS09300 Protein ID WP_000581792.1
Coordinates 1827244..1827453 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag E3S67_RS09305 Protein ID WP_000138932.1
Coordinates 1827465..1827758 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3S67_RS09280 1822752..1824110 - 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
E3S67_RS09285 1824125..1825195 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
E3S67_RS09290 1825513..1826715 + 1203 WP_001109939.1 rod shape-determining protein RodA -
E3S67_RS09295 1826979..1827116 - 138 WP_000828354.1 hypothetical protein -
E3S67_RS09300 1827244..1827453 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
E3S67_RS09305 1827465..1827758 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3S67_RS09310 1827924..1829408 + 1485 WP_000571549.1 cardiolipin synthase -
E3S67_RS09315 1829436..1830083 + 648 WP_001187630.1 HD domain-containing protein -
E3S67_RS09335 1830996..1831868 - 873 WP_000725802.1 membrane protein insertase YidC -
E3S67_RS09340 1831954..1832595 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T147947 WP_000581792.1 NZ_CP047802:c1827453-1827244 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147947 NZ_CP063380:c213242-211923 [Pectobacterium versatile]
ATGGCTGCGCTCGATGTTTACATGAACGGCTATCGGGTGGGGATTCTGACCAAAACGGGCAGTGGAGCACATCATTTTTC
CTATGATGCGAACTGGCTCGGGTTGCCGGGGAGTCGCCCCATTTCGCTTTCTATGCCGCTACGTCATCAGTCCTATCAAG
GTGATGAGGTTTATAACTTCTTCGACAATTTGTTGCCAGATAACCCGGATATCAGAAGACGGATTGTCGCCAGGCATCAC
GCGGATTCCACCCAACCGTTTGATCTGCTGGATAAAGTGGGGAAAGACAGTGTCGGGGCGTTGCAAATAGTGCCGCAGGG
TACACCTGTGCACGATATAAAAAAGATCGAATACAAAACCTTATCCGAGCAGCAGCTTGAAAACATACTGGCGGGATACC
TGTCCGATGCCCCGCTGGGTATGATTGATACTGAAGACGATTTTCGTATCTCTATCGCGGGCGCACAGGAAAAGACGGCG
CTGCTTTATCTGGATGATCACTGGTGCCTGCCCTTCAGTACCACACCAACTACCCACATCATCAAGCTACCGATTGGTAA
AATCGAGAGTCACTCTTACTCAATTGATATGTCTGACAGCGTTGAAAATGAGTATCTGTGCCTGCTCATTGCCAAGGCAT
TTGGGCTGCCAGTGCCGCACTGTTTTATGATCAACGCTGGCAAGATAAAGGCGTTGGCGGTGGAGCGTTTTGATCGTAAA
TACGCCTCGGATGTCAGTTGGATTATGCGGCTACCACAAGAGGATTTTTGTCAGGTATTAAACGTTCCTTCCGCACTGAA
ATATGAAAATCATGGTGGACCGGGTATTTCCGCCATTATGTCGTTTCTATTGGGGTCGGTTGATCCAGAAAGAGATCGTT
ATCGCTTTATGCAGGCTCAGGTACTGTTTTGGCTATTGGCTGCAACGGATGGTCATGCGAAAAACTTTTCCCTGTTTATT
GAATCTGAGGGGCGATATCGACTCACACCTTTCTATGACATTCTCTCTATGTATCCGGCGATGGGCGGACGGGGAATTGA
CCGCAGAGAGGCCAAACTGGCGATGGGATTAACTGGCTCAAGAGGCAAGAAATATGCGATTGAGCAGATCTTTCCCCGGC
ATTTTTTCCAGACGGCGAAGGCCGTTGGGTTTGCCAGAGAATCAATGGAAAACATTCTGGCGGAGTTTGCACAAACCGTT
GAGACCGTTATGACGACTGTTGGAAGCCAACTGCCTGTGGATTTTCCTACTCATATCAGTGAGGCAATTCTGGCCGGATT
GCAGGCCAGATCGAGACGGCTCATGAGCGGATGGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT147947 WP_000138932.1 NZ_CP047802:c1827758-1827465 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147947 NZ_CP063380:c213508-213242 [Pectobacterium versatile]
ATGAAGGTCACCAACAGCAAGCAGCTTAGCAGCTACCTGAAAGATGTTCGTATCACGCAGAAGCTTTCACAAGGGAAAGT
GGCCAGTAAAGTGGGTATTCGCCAGGATACGGTATCCAGCTTCGAGCAACATCCTGATTCCACCAAGCTGGAAACCTTCT
TTAAAATCCTGTCGGCATTGAACTTAGAACTTACTGTTACGCCCCGAAATGTGGATACCGCCAATAACGAAGCCTCTGTT
GCATCATCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References