Detailed information of TA system TA147643

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 2056631..2057145
• Replicon: chromosome
• Accession: NZ_CP047783
• Organism: Staphylococcus aureus strain UP_1313

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: T1YA99
• Locus tag: E3T03_RS09955
• Protein ID: WP_000581792.1
• Coordinates: 2056631..2056840 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A0D1GBN9
• Locus tag: E3T03_RS09960
• Protein ID: WP_000138934.1
• Coordinates: 2056852..2057145 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3T03_RS09935	2052139..2053497	-	1359	WP_000611468.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-
E3T03_RS09940	2053512..2054582	-	1071	WP_000159641.1	D-alanine--D-alanine ligase	-
E3T03_RS09945	2054900..2056102	+	1203	WP_001109939.1	rod shape-determining protein RodA	-
E3T03_RS09950	2056366..2056503	-	138	WP_000828354.1	hypothetical protein	-
E3T03_RS09955	2056631..2056840	-	210	WP_000581792.1	heavy-metal-associated domain-containing protein	Toxin
E3T03_RS09960	2056852..2057145	-	294	WP_000138934.1	copper-sensing transcriptional repressor CsoR	Antitoxin
E3T03_RS09965	2057311..2058795	+	1485	WP_000571549.1	cardiolipin synthase	-
E3T03_RS09970	2058823..2059470	+	648	WP_001187610.1	HD domain-containing protein	-
E3T03_RS09990	2060285..2061157	-	873	WP_000725802.1	membrane protein insertase YidC	-
E3T03_RS09995	2061243..2061884	-	642	WP_000483147.1	thiamine phosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (23-66)

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7843.77 Da
• Isoelectric Point: 4.1008

>T147643 WP_000581792.1 NZ_CP047783:c2056840-2056631 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Nucleotide

• Length: 210 bp

>T147643 NZ_CP063158:2338351-2339088 [Bacillus cereus]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTATACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACACCTAATATTTCTGAAATATGGGGTGCGAAATTTACCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACGACAATTATTCAAAATGTTAACCCATCAGTATTCGGTACGATGG
AATGGCATACAGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATATGGGGAAAAAATTGGTGCGAAAATT
GTTGTTTTTGAAGCCGCGAAAGAATTAAATACAAACTTTCGGGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGACG
TTTTCATTATTATTGATGGAAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11185.77 Da
• Isoelectric Point: 6.2243

>AT147643 WP_000138934.1 NZ_CP047783:c2057145-2056852 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Nucleotide

• Length: 294 bp

>AT147643 NZ_CP063158:2339201-2339329 [Bacillus cereus]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Structures

Toxin

• PDB: 6FF1

Antitoxin

• AlphaFold DB: A0A0D1GBN9