147643

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2056631..2057145 Replicon chromosome
Accession NZ_CP047783
Organism Staphylococcus aureus strain UP_1313

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag E3T03_RS09955 Protein ID WP_000581792.1
Coordinates 2056631..2056840 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag E3T03_RS09960 Protein ID WP_000138934.1
Coordinates 2056852..2057145 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3T03_RS09935 2052139..2053497 - 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
E3T03_RS09940 2053512..2054582 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
E3T03_RS09945 2054900..2056102 + 1203 WP_001109939.1 rod shape-determining protein RodA -
E3T03_RS09950 2056366..2056503 - 138 WP_000828354.1 hypothetical protein -
E3T03_RS09955 2056631..2056840 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
E3T03_RS09960 2056852..2057145 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
E3T03_RS09965 2057311..2058795 + 1485 WP_000571549.1 cardiolipin synthase -
E3T03_RS09970 2058823..2059470 + 648 WP_001187610.1 HD domain-containing protein -
E3T03_RS09990 2060285..2061157 - 873 WP_000725802.1 membrane protein insertase YidC -
E3T03_RS09995 2061243..2061884 - 642 WP_000483147.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T147643 WP_000581792.1 NZ_CP047783:c2056840-2056631 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T147643 NZ_CP063158:2338351-2339088 [Bacillus cereus]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTATACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATTGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACACCTAATATTTCTGAAATATGGGGTGCGAAATTTACCGATATTGGCAAGACAGTTCAATCAATAAAACGATC
ATTAATTGCATCTAAAGCGAGAGGAGAAATATACACGACAATTATTCAAAATGTTAACCCATCAGTATTCGGTACGATGG
AATGGCATACAGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATATGGGGAAAAAATTGGTGCGAAAATT
GTTGTTTTTGAAGCCGCGAAAGAATTAAATACAAACTTTCGGGGTATTCGCTCGCAATTTAGTATTATCGTTCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTAGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGACG
TTTTCATTATTATTGATGGAAAGAAAAATAACCTGCAAGATCGAGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT147643 WP_000138934.1 NZ_CP047783:c2057145-2056852 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT147643 NZ_CP063158:2339201-2339329 [Bacillus cereus]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAAGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References